CBD is fat-soluble, so a small portion may get stored in fat cells. The cannabinoid can stay in your system for a little longer if you have a high body fat percentage.
The higher the concentration of a CBD oil or supplement, the longer it takes your liver to process, and the longer active ingredients stay in your system.
Using the information obtained while measuring CBD’s half-life, scientists can work out how long CBD stays in the body. You cannot do this yourself at home, but we can use their data to provide a general timeframe.
How long does CBD stay in your system?
Our metabolism is a combination of chemical reactions, one of which includes the conversion of food to energy. The faster your metabolism, the quicker substances (including CBD) are broken down, processed and eliminated.
In another study, half-life of CBD was evaluated based on a single dose in the amount of 20mg and 18.8–19.4mg administered intravenously and smoked respectively. The half-life was accordingly estimated at 18–30h and 27–35h.
• Amount of CBD consumed
• Purity and strength of the oil/supplement you’re using
No , drug tests do not screen for CBD, so you don’t have to worry about how long CBD is detectable in urine. Drug tests only screen for THC and its related metabolites in urine, blood, or hair.
Very high doses will stay in your body longer, and your height, weight, and metabolism will also influence how long CBD stays in your system. Generally speaking, the faster your metabolism and the lower your body weight, the quicker CBD will be out of your system.
CBD oil vs. Hemp oil vs. THC oil: what’s the difference?
CBD oil is an oil that contains concentrated cannabidiol, or CBD, which is extracted from the leaves and stem of the hemp plant. CBD oil is non-psychoactive, and is a powerful anti-inflammatory that provides a range of medical benefits.
Hemp oil is a seed oil made from the seed of the hemp plant, and is commonly used in cooking. While hemp oil is highly nutritious, it does not contain CBD or THC, and does not have medicinal properties.
BUT, there’s something else to keep in mind: there are cases of people using only CBD oil testing positive for THC metabolites in drug tests. This is likely due to CBD products that contain trace amounts of THC. One way to avoid this is to check the label of any CBD product you buy for a guarantee that it is THC-free.
Conclusions: This review highlights the paucity in data and some discrepancy in the pharmacokinetics of cannabidiol, despite its widespread use in humans. Analysis and understanding of properties such as bioavailability and half-life is critical to future therapeutic success, and robust data from a variety of formulations is required.
The systematic review was carried out in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (Moher et al., 2009). A systematic search of PubMed and EMBASE (including MEDLINE) was conducted to retrieve all articles reporting pharmacokinetic data of CBD in humans. Search terms included: CBD, cannabidiol, Epidiolex, pharmacokinetics, Cmax, plasma concentrations, plasma levels, half-life, peak concentrations, absorption, bioavailability, AUC, Tmax, Cmin, and apparent volume of distribution. No restrictions were applied to type of study, publication year, or language. The searches were carried out by 14 March 2018 by two independent researchers.
The highest plasma concentrations of CBD were reported by Ohlsson et al. following i.v. administration of 20 mg of deuterium-labeled CBD. Mean plasma CBD concentrations were reported at 686 ng/mL (3 min post-administration), which dropped to 48 ng/mL at 1 h.
Plasma apparent clearance, CL/F (L/h) has been reported to range from 2,546 to 4,741 in a fasted stated following 10 mg CBD administered via oromucosal spray (Stott et al., 2013a,c). This value decreases to 533 following the same concentration in a fed state (Stott et al., 2013b). A plasma apparent clearance of 3,252 and 3,783 was reported following 5 and 20 mg single doses of CBD via oromucosal spray (Stott et al., 2013a). Ohlsson et al. reported plasma apparent clearance as 74.4 L/h following i.v. injection (Ohlsson et al., 1986).
AUC0−inf: The area under the plasma concentration vs. time curve from zero to t calculated as AUC0−t plus the extrapolated amount from time t to infinity.