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synergetic cbd oil

EU Office
Synergetic Phyto
Vlotlaan 605
Monster
Netherlands

CBD Melting Tabs are one of the most convenient ways to get CBD into the system. With a set mg content per tab and an easy delivery method ensures exact dosing every time a tablet is consumed.

Synergetic products are derived from specifically bred Industrial Hemp plants with high levels of CBD. Our cannabis is grown organically and extracted via clean Co2 to bring the purest, cannabinoid and terpene rich products to the market – all while maintaining cGMP standards and practices.

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Available in 20ml, natural flavour and 3 strengths; 500mg, 1000mg and 1500mg

CBD Chewing Gum is great tasting way to get CBD into the system. With a set mg content per tab and an easy delivery method ensures exact dosing every time a piece of gum is consumed. Made with peppermint for a fresh mint taste, Synergetic CBD Chewing Gum absorbs quickly into the body and is effective for those on the move.

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Available across selected outlets within the UK and EU

Spray the 500mg Synergetic CBD oil 1-2 times under your tongue and hold there for up to 60 seconds. Repeat once in the morning, and once in the evening.

IMPORTANT FOR WOMEN: If you are taking the contraceptive pill, CBD may make this less effective. While it will not stop the pill from working completely, it is advised to still air on side of caution and protect yourself. Worth thinking about when taking the Loveburgh CBD Paste!

CBD does not affect most drugs or medicines, but there are a few that can be affected by CBD. CBD as a natural substance is not alone in its ability to change the way in which the liver works- Grapefruit, Watercress, St John Wort and Goldenseal also do the same. Many drugs are metabolized into the body in the Liver- CBD is metabolized by the Cytochrome P450 system which is a pathway that plenty of drugs take. CBD can affect the process in which other drugs are processed. It can make the absorption faster, or slower than they would be on their own. This can either mean that the drugs you are taking stay in your bloodstream for longer or there will be a reduction in their absorption. Therefore taking CBD could lead to medicine becoming hyper-effective and leading to higher levels of drugs in your bloodstream than expected or could mean that your medication stops working/works less effectively. For more information please speak to a trained health professional to access more information about the P450 system.

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Instructions of Use

The advice that we always give is to start low and slow- this 500mg CBD oil is the perfect product for beginners. The Synergetic Phytocannabinoids CBD oil has been produced from organic industrial hemp plants and CO2 extraction methods which produce the purest cannabinoid and terpene-rich on the market. Although quite a refined oil, the 500mg Synergetic Spray is derived from a whole-plant extract which means that it contains all of the synergistic essential oils, cannabinoids and naturally occurring compounds from the plant. Similar products are produced using Isolated CBD

The absorption rate of the oil has been improved even more by the atomiser spray head which increases the surface area that the oil covers when it is sprayed under the tongue. It is a much easier, and cleaner, was to dose and use compared to a dropper.

If you are taking prescribed or regular medication you should consult a trusted medical professional before starting a course of CBD food supplements. Do not stop taking medication to replace it with CBD. Do not take this product if you are pregnant or nursing.

The broad-spectrum CBD formula is suspended in an MCT oil which dramatically increases the bioavailability of the CBD. MCT oil is a fractioned version of Coconut oil and is the ideal energy source for the human body. It is very easily broken down into the body and is absorbed very quickly. It on its own is one of the healthiest substances on the planet. It is also has a very light and floral flavour compared to hemp seed oils.

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The European Pharmacopoeia, Sixth Edition (2007), lists 28 EOs (Pauli and Schilcher, 2010). Terpenoids are pharmacologically versatile: they are lipophilic, interact with cell membranes, neuronal and muscle ion channels, neurotransmitter receptors, G-protein coupled (odorant) receptors, second messenger systems and enzymes (Bowles, 2003; Buchbauer, 2010). All the terpenoids discussed herein are Generally Recognized as Safe, as attested by the US Food and Drug Administration as food additives, or by the Food and Extract Manufacturers Association and other world regulatory bodies. Germane is the observation (Adams and Taylor, 2010) (p. 193), ‘With a high degree of confidence one may presume that EOs derived from food are likely to be safe’. Additionally, all the current entries are non-sensitizing to skin when fresh (Tisserand and Balacs, 1995; Adams and Taylor, 2010), but may cause allergic reactions at very low rates when oxidized (Matura et al., 2005). For additional pharmacological data on other common cannabis terpenoids not discussed herein (1,8-cineole, also known as eucalyptol, pulegone, α-terpineol, terpineol-4-ol, ρ-cymene, borneol and Δ-3-carene), please see McPartland and Russo (2001b).

The effects of cannabis on sleep have been reviewed (Russo et al., 2007), and highlight the benefits that can accrue in this regard, particularly with respect to symptom reduction permitting better sleep, as opposed to a mere hypnotic effect. Certainly, terpenoids with pain-relieving, anti-anxiety or sedative effects may supplement such activity, notably, caryophyllene, linalool and myrcene.

Cannabis terpenoids: neglected entourage compounds?

Is cannabis merely a crude vehicle for delivery of THC? Might it rather display herbal synergy (Williamson, 2001) encompassing potentiation of activity by active or inactive components, antagonism (evidenced by the ability of CBD to reduce side effects of THC; Russo and Guy, 2006), summation, pharmacokinetic and metabolic interactions? Recently, four basic mechanisms of synergy have been proposed (Wagner and Ulrich-Merzenich, 2009): (i) multi-target effects; (ii) pharmacokinetic effects such as improved solubility or bioavailability; (iii) agent interactions affecting bacterial resistance; and (iv) modulation of adverse events. Cannabis was cited as an illustration.

d -limonene, common to the lemon and other citrus EOs ( Table 2 ), is the second most widely distributed terpenoid in nature (Noma and Asakawa, 2010), and is the precursor to other monoterpenoids ( Figure 2 ) through species-specific synthetic schemes. Unfortunately, these pathways have not yet been investigated in cannabis. The ubiquity of limonene serves, perhaps, as a demonstration of convergent evolution that supports an important ecological role for this monoterpene. Studies with varying methodology and dosing in citrus oils in mice suggest it to be a powerful anxiolytic agent (Carvalho-Freitas and Costa, 2002; Pultrini Ade et al., 2006), with one EO increasing serotonin in the prefrontal cortex, and dopamine (DA) in hippocampus mediated via 5-HT1A (Komiya et al., 2006). Compelling confirmatory evidence in humans was provided in a clinical study (Komori et al., 1995), in which hospitalized depressed patients were exposed to citrus fragrance in ambient air, with subsequent normalization of Hamilton Depression Scores, successful discontinuation of antidepressant medication in 9/12 patients and serum evidence of immune stimulation (CD4/8 ratio normalization). Limonene also produces apoptosis of breast cancer cells, and was employed at high doses in Phase II RCTs (Vigushin et al., 1998). Subsequent investigation in cancer treatment has centred on its immediate hepatic metabolite, perillic acid, which demonstrates anti-stress effects in rat brain (Fukumoto et al., 2008). A patent has been submitted, claiming that limonene effectively treats gastro-oesophageal reflux (Harris, 2010). Citrus EOs containing limonene proved effective against dermatophytes (Sanguinetti et al., 2007; Singh et al., 2010), and citrus EOs with terpenoid profiles resembling those in cannabis demonstrated strong radical scavenging properties (Choi et al., 2000). As noted above, limonene is highly bioavailable (Falk-Filipsson et al., 1993), and rapidly metabolized, but with indications of accumulation and retention in adipose tissues (e.g. brain). It is highly non-toxic (estimated human lethal dose 0.5–5 g·kg −1 ) and non-sensitizing (Von Burg, 1995)

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Nerolidol is a sesquiterpene alcohol with sedative properties (Binet et al., 1972), present as a low-level component in orange and other citrus peels ( Table 2 ). It diminished experimentally induced formation of colon adenomas in rats (Wattenberg, 1991). It was an effective agent for enhancing skin penetration of 5-fluorouracil (Cornwell and Barry, 1994). This could be a helpful property in treating fungal growth, where it is also an inhibitor (Langenheim, 1994). It seems to have anti-protozoal parasite control benefits, as a potent antimalarial (Lopes et al., 1999; Rodrigues Goulart et al., 2004) and anti-leishmanial agent (Arruda et al., 2005). Nerolidol is non-toxic and non-sensitizing (Lapczynski et al., 2008).