Remember, because CBD oils are largely unregulated, there is no guarantee that a product is either safe or effective.
CBD’s exact mechanism of action is unclear. Unlike THC, CBD has a relatively low affinity for cannabinoid receptors in the brain. These are the molecules to which THC binds to elicit its psychoactive effects.
To determine an exact dose of CBD, remember that each drop of oil equals 0.05 mL of fluid. This means that a 30-mL bottle of CBD oil will have roughly 600 drops. If the concentration of the tincture is 1,500 mg/mL, one drop would contain 2.5 mg of CBD (1,500 mg ÷ 600 drops = 2.5 mg).
What to Look For
Instead, CBD is thought to influence other receptors, including opioid receptors that regulate pain and glycine receptors involved in the regulation of the “feel-good” hormone and neurotransmitter serotonin.
To use CBD oil, place one or more drops under the tongue and hold the dose there for 30 to 60 seconds without swallowing. Capsules and gummies are easier to dose, although they tend to be more costly. CBD sublingual sprays are available as well.
CBD oil may also increase liver enzymes (a marker of liver inflammation). People with liver disease should use CBD oil with caution, ideally under the care of a doctor who can regularly check blood liver enzyme levels.
CBD oil should be avoided during pregnancy and breastfeeding. A 2018 study from the American Academy of Pediatrics warned women to avoid marijuana during pregnancy due to the potential risks to a baby’s development. Although it is unclear how CBD contributes, CBD is known to pass through the placental barrier.
One of the potentially confusing areas in the world of CBD has to do with CBD tincture vs CBD oil. The primary difference between the two has to do with how they are produced.
Finally, it’s basically impossible to overdose on CBD, regardless of what form it’s in. Studies found that CBD had no adverse side effects at amounts up to 1200 milligrams daily, even when taken for several months.
How to take CBD oil
The first official record of cannabis tinctures used in Western medicine appeared in an 1843 medical journal. The journal featured a recipe, and soon after its publication, apothecaries and medicine producers began to make and sell their own versions of the product.
Read the label to understand more about the CBD in your tincture. Remember there are many different products available today, so pay attention to the type of CBD extract you’re purchasing. There are three primary types of extract:
Tinctures are made using alcohol as a solvent. Plant material is soaked in high-proof alcohol for an extended period of time. As it soaks, the alcohol pulls out many of the chemicals contained in the plant material. The final product contains a very high percentage of alcohol plus all the chemicals extracted from the plant — including cannabinoids and terpenes. Producers sometimes add flavors, sweeteners, essential oils, or other chemicals to the final product to enhance the flavor or create a different set of effects.