Does CBD Oil Interact With Phenobarbital In Dogs

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What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some. Cannabidiol (CBD) and the barbiturate phenobarbital carry a high risk of interacting. It’s wise to avoid using CBD if you’ve been prescribed Luminal. Hello, everyone! This week I want to talk to you about CBD oil for dogs. Specifically, I would like to address how CBD oil could significantly help your dog wit

Can my Dog take CBD Oil While Taking Other Medications?

With the pet CBD market industry exploding globally, it’s no surprise that we need to look out for any drug interactions. What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some.

In this blog, we’ll discuss why it’s important to consult with your veterinarian first before using CBD pet products.

Not only is this important so that you can get a proper diagnosis for a medical condition, but your veterinarian will be able to discuss any possible side effects if CBD is used together with other pet meds.

Here’s what you need to know to fully protect your pet, and to make sure that there are no drug interactions.

CBD can alter the way your dog processes certain medications

Yes, although cannabidiol (CBD) is a natural supplement that is beneficial for numerous health conditions in pets, as well as for chronic pain, insomnia, depression , and anxiety, CBD does have the potential to interact with certain medications.

CBD is derived from the hemp plant, yet it can also come from the marijuana plant. CBD hardly ever contains delta-9-tetrahydrocannabinol (THC), which is the compound that gives marijuana its “high” effect. High-quality CBD is non-toxic and considered safe for pets and humans alike.

There are almost no side-effects, apart from those coming from a low-quality CBD oil that may contain contaminants. It’s always best to look out for the compromised quality of some CBD oils.

You’ll need to discuss with your veterinarian all supplements, over-the-counter meds and prescription meds that your pet may be taking. Today research continues to demonstrate how effective CBD oil is for pets, yet one still needs to examine how it can interfere with the metabolism of pet meds and other supplements.

Benefits of CBD Oil for Dogs

Cannabidiol (CBD) extract is quickly gaining popularity as a natural alternative for managing pain, inflammation, and a variety of medical conditions, including epilepsy. However, recent reports have called into question the safety of CBD when used together with other pet meds. It’s also good to note that using a compromised quality or low-quality CBD oil raises the risk of side effects.

A recent 2019 study by the University of Korea, demonstrates that the CBD anti-cancer protein shows potential in killing tumor cells. The researchers tested the synergistic effect of CBD with a cancer destroying protein called TRAIL. (TNF related apoptosis- inducing ligand.)

The study concluded that TRAIL and CBD created apoptosis separately in colorectal cancer cells. The researchers also found that together, both reduced cancer cells a lot. “ To the best of our knowledge,” they wrote, “this is the first report that cannabidiol induces significant TRAIL-induced apoptosis of colorectal cancer cells,” noting that earlier reports suggested that a different protein response was responsible for cancer-cell death.” via MDPI Journals.

FDA & CBD

The FDA has also tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to have. We have also heard reports of CBD potentially containing contaminants (e.g., pesticides, heavy metals); we are looking into this.

Some cannabis products are also being marketed as pet food and health products for animals. The FDA has not approved cannabis for any use in animals and recommends pet owners talk with their veterinarians about appropriate treatment options for their pets.” via FDA, 2019.

Blood Pressure and CBD Oil

High doses of CBD oil may potentially drop blood pressure resulting in lightheadedness and possibly dizziness in people. It’s always best to consult with your veterinarian for the best advice prior to purchasing a CBD product. That said, the positive side of CBD oil use is that it may be good for patients with high blood pressure. CBD together with regular exercise and a healthy diet help to regulate hypertension.

A 2017 study by Dr. K Jadoon on CBD and its effects on blood pressure demonstrated the following:

The study concludes that “acute administration of CBD reduces resting BP and the BP increases stress in humans, associated with increased HR. These hemodynamic changes should be considered for people taking CBD. Further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders.”

CBD Oil Interacts with Anti-Seizure Meds

A study researching CBD interactions with seizure meds in people added that “ Because all of the participants are also taking other seizure drugs while they are receiving the investigational therapy, investigators checked the blood levels of their other seizure drugs to see if they changed. “With any new potential seizure medication, it is important to know if drug interactions exist and if there are labs that should be monitored while taking a specific medication,” said lead author Tyler Gaston, MD,” via Science Daily.

Dr. Gaston and her colleagues found that there were significant changes in levels of the drugs clobazam (and its active metabolite N-desmethylclobazam), topiramate, and rufinamide in both adults and children, and zonisamide and eslicarbazepine in adults only.

Except for clobazam/desmethylclobazam, however, the drug levels did not change outside of the normally accepted range. In addition, adult participants in the study taking clobazam reported sedation more frequently.

Additionally, when seizure patients were using valproate, they added that “Tests also showed that participants taking valproate and CBD had higher ALT and AST (liver function tests) compared with participants not taking valproate.

Very high ALT and AST indicate abnormal liver function, but significant ALT and AST elevation occurred only in a small number of participants (4 children and 1 adult), and the levels returned to normal after discontinuation of valproate and CBD.”

The study concludes that “The findings emphasize the importance of monitoring blood levels of antiepileptic drugs as well as liver function during treatment with CBD. “

A perception exists that since CBD is plant based, that it is natural and safe; and while this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of,” said Dr. Gaston.”

Cytochrome P450

CBD as a natural supplement does not cause a “high” in pets, but may cause a reaction when used together with anti-seizure meds. Cannabinoids have been shown to inhibit cytochrome P450 enzymes by using up these enzymes, and by inhibiting how other enzymes work.

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When cannabidiol oil is consumed by dogs in large amounts, a large group of enzymes may be altered in the same way that grapefruit alters enzymes.

Most pet meds are metabolized in the liver via certain enzymes that are made in it. CBD works in the same way that grapefruit does, and may use up all the enzymes and also alter the effectiveness of pet meds.

NSAIDs and Corticosteroids

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs commonly used to control pain and inflammation in dogs. NSAIDs help many dogs lead a life that is more comfortable for them, but what about interactions with CBD oil? CBD oil has the potential to make pet meds less effective.

That said, pet parents should take every precaution to ensure that there are no interactions with any of their pet meds or supplements, and even NSAID’s, corticosteroids, pet herbal supplements and vitamins. The potential for adverse reactions will also depend on the body chemistry of your pet and the dose of the prescription or supplement.

Administer CBD oil 2 hours before or 2 hours after giving pet meds or supplements.

NSAID’S include the following:

  • Rimadyl
  • Metacam,
  • Deramaxx,
  • Etogesic

Meds like Gabapentin when taken together with CBD can cause lethargy in pets. It’s important to discuss CBD use with your veterinarian prior to administering.

Common corticosteroids include the following:

  • Prednisone
  • Triamcinolone,
  • Dexamethasone,

The most common symptoms when using these are gastrointestinal issues like lack of appetite, vomiting, diarrhea, and even ulcers. We all know that pets cannot take both NSAID’s and corticosteroids at the same time, but what about cannabidiol oil and NSAID’s and corticosteroids?

CBD oil can also enhance the effectiveness of certain drugs and one may be able to lower the dose of pet meds or therapy when using CBD oil. Pet meds that are used for pain relief need to be administered carefully when using them together with CBD oil.

Does CBD Interact With Phenobarbital (Luminal)?

CBD may interfere with the body’s ability to metabolize phenobarbital.

This interaction is considered risky and should be avoided whenever possible.

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Phenobarbital (Luminal) is a long-acting anticonvulsant drug used to treat most types of seizures. It’s one of the oldest used anticonvulsant drugs still in use today.

Phenobarbital and CBD require the same enzymes for metabolism and may therefore interact.

Taking both substances together will increase the chances of experiencing side effects — some of which may require medical attention.

Table of Contents

Does CBD Interact With Phenobarbital (Luminal)?

Yes. CBD can interact with phenobarbital.

CBD can increase the level of phenobarbital in the blood by slowing its metabolism and potentiating some of the side effects.

The most concerning side effects possible from this interaction are liver damage, hyperactivity, confusion, and lapses in memory.

CBD interacts with phenobarbital in two ways:

A) Increase in the Effects of Phenobarbital (Agonistic Interaction)

CBD and barbiturates exert similar effects on the body. Both compounds have an inhibitory action on the central nervous system — causing users to feel calm and relaxed in normal doses and sedated in higher doses.

If two central nervous system depressants are combined, the sedative action could become too strong — leading to side effects.

B) Slowed Elimination (Metabolic Competition)

The cytochrome P450 enzymes are responsible for metabolizing most of the drugs in the body. Several drugs may use the same enzymes for metabolism, and taking them together can cause these drugs to compete against each other for the said enzymes. This causes their metabolism to slow down.

The enzymes CYP2C9, CYP2C19, and CYP2E1 are responsible for metabolizing phenobarbital in the body. CBD also gets metabolized by CYP2C19 and CYP2C9 too, as well as other enzymes, including CYP3A4.

Because of the overlap, it’s possible that taking CBD and phenobarbital together will result in both substances competing for metabolism via the CYP450 enzymes — leading to slowed metabolism and elimination of both compounds.

Similar Medications: CBD & Barbiturates

Phenobarbital is classified as a barbiturate. CBD and barbiturates all share similar risks for interaction and side effects. It is used for treating seizure disorders and is used as a sedative and hypnotic.

Here’s a list of similar medications that share a similar level of risk when combined with CBD:

  • Amobarbital (Amytal Sodium)
  • Butabarbital (Butisol Sodium)
  • Mephobarbital (Mebaral)
  • Pentobarbital (Nembutal Sodium)
  • Secobarbital (Seconal)

Is It Safe to Take CBD and Phenobarbital (Luminal) Together?

No, CBD and phenobarbital are not safe to be taken together.

Using CBD and phenobarbital together can have a high risk of interaction. CBD can raise phenobarbital levels in the body to unhealthy levels.

If you’ve been given a prescription for phenobarbital, it’s wise to speak to your doctor about using CBD or any other supplements first. Your doctor can assess your individual level of risk based on other health factors, family history, and underlying health conditions to determine if it’s safe to use CBD or not.

Is CBD A Viable Alternative to Phenobarbital (Luminal)?

While CBD doesn’t even come close to the potency of phenobarbital, there’s plenty of evidence that it can support many of the same disorders.

Many people turn to CBD or other non-toxic and non-addictive substances first before moving on to strong pharmaceuticals like Luminal. In many cases, CBD offers enough relief to avoid using phenobarbital. CBD is less specific and less potent than phenobarbital, so it may require a few days of treatment before seeing improvements.

CBD has received approval for use in the treatment of two seizure disorders, Lennox-Gastaut syndrome and Dravet syndrome. Studies have shown that using CBD as an adjunct in patients with Lennox-Gastaut syndrome decreased their seizures significantly [1].

CBD’s sedative effects on the nervous system have been shown to induce better sleep in users suffering from sleep disorders [2].

However, it may not be useful in severe cases of seizure disorders that need stronger drugs like phenobarbital.

What is Phenobarbital (Luminal)?

Phenobarbital is a prescription-only anticonvulsant drug belonging to the barbiturate class. It’s one of the oldest anticonvulsants still in use today. Luminal (the most common brand name for this medication) is used to treat various kinds of seizure disorders.

Phenobarbital (Luminal) Specs:

Drug Name Phenobarbital
Trade Names Luminal, Epitan, Gardenal, Hypnobarb, Phenoseize, Pheno, Donnatal, Phenobarb, Phenohytro
Classification Barbiturates
CYP Metabolism CYP2C9, CYP2C19, CYP2E1
Interaction With CBD Metabolic competition, Agonist
Risk of Interaction High

What Does Phenobarbital (Luminal) Do?

Phenobarbital is a long-acting barbiturate and is used as an anticonvulsant, sedative, and hypnotic. It’s used to treat most types of seizure disorders, with the exception of absence seizures (it could make them worse).

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Phenobarbital may cause sedative and hypnotic effects by acting on the polysynaptic midbrain reticular formation, which controls CNS arousal.

Phenobarbital works by increasing the amount of time the chloride ion channel remains open. It does this by interacting with gamma-aminobutyric acid-A (GABAA) receptor subunits.

Because of this, phenobarbital can increase the flow of chloride ions into the neuron, decreasing the excitability of the postsynaptic neuron. Hyperpolarizing this postsynaptic membrane decreases the general excitation of the postsynaptic neuron. It makes it harder for it to depolarize the neuron, causing the threshold for the action potential of the postsynaptic neuron to increase.

Phenobarbital stimulates GABA to create this hyperpolarization. It also directly blocks excitatory glutamate signaling, causing hypnotic and anticonvulsant effects. This ability increases the threshold of seizure and reduces its spread from a seizure focus.

Phenobarbital may also inhibit calcium channels, decreasing the release of excitatory transmitters.

Its use must be monitored very carefully as it can cause decreased levels of consciousness and decreased respiratory competency.

Side Effects of Phenobarbital (Luminal)

Phenobarbital can cause dependence and addiction. Phenobarbital is prone to abuse following long-term use.

Stopping the drug abruptly can cause withdrawal symptoms such as tremors, nausea, restlessness, etc. This can be avoided or reduced by lowering the amount used very slowly over a long period.

It may also increase the risk of suicide. It is not recommended for use in pregnancy and breastfeeding. It must be used with caution and in low doses in users with poor liver or renal function. It is contraindicated in severe respiratory depression, hypersensitivity, and porphyria.

Side effects of Phenobarbital (Luminal)

  • Ataxia
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dysarthria
  • Fatigue
  • Headache
  • Hepatotoxicity
  • Hypersensitivity
  • Hypocalcemia
  • Irritability
  • Megaloblastic anemia
  • Mental dullness
  • Memory lapse
  • Nausea
  • Nystagmus
  • Osteomalacia
  • Paradoxical excitement, hyperactivity in younger patients
  • Paresthesia
  • Rash
  • Respiratory depression
  • Restlessness
  • Rickets
  • Vertigo
  • Vomiting

Key Takeaways: Is it Safe to Take Phenobarbital (Luminal) With CBD?

It’s unsafe to take CBD with phenobarbital as they have a high risk of interaction. CBD can slow down the metabolism and elimination of phenobarbital — making it more potent and increasing the risk of side effects.

Take these two drugs together only if recommended by your prescribing physician, and never take them on your own accord. In such conditions, side effects may be reduced by using a minimal dosage of both drugs. If you experience any unusual side effects after using phenobarbital and CBD together, seek medical attention immediately.

CBD has been approved to treat two seizure disorders, but its use in treating other seizure disorders like phenobarbital is a topic that needs more research.

Can CBD Oil Help Dogs With Seizures?

Hello, everyone! This week I want to talk to you about CBD oil for dogs. Specifically, I would like to address how CBD oil could significantly help your dog with epilepsy.

Before going on with the article, I want to let you know as a Canine Behaviorist, I work closely with veterinarians, and highly recommend talking to a veterinarian before implementing CBD oil into your dog’s routine to ensure it’s the best solution for your individual dog (remember, all dogs are different).

I also highlight CannaCanine’s CBD oil in this article. I do not earn any commission on their sales, but I have received a handful of different CBD products for dogs and their product is by far the highest-quality product. I am so impressed with CannaCanine’s product I have taken them on as a client writing content for their organization.

With this said, let’s move on to the article.

Did you know one to five percent of dogs have a seizure disorder? This may sound like a small percentage, but when you think about how many dogs there are, that’s way too many.

Watching your dog have a seizure is frightening. You’re watching your dog go through a traumatic experience. You feel out of control, and you’re not sure what to do to help them if you’re not familiar with this condition.

If your dog has never had a seizure before, you should still understand what should be done in case of an episode. If you notice your dog experiencing a seizure, try to be calm (keep in mind your dog can ‘feel’ your emotions) and observe his surroundings to ensure there’s nothing in reach that could cause harm. You should also watch where your hands are. Your dog could accidentally bite you as he or she will not have control over his/her body during this time.

When we adopt our dogs, serious conditions like seizures aren’t usually our main concern. But, learning about everything that could affect our dogs and how to help is important.

If you’re unsure of what a seizure looks like, you’ll generally notice: collapsing, stiff muscles, jerking movements, loss of consciousness, foaming at the mouth, and/or a confused gaze. She might appear as if she’s looking out into space… as if she’s in another dimension.

After a dog has a seizure, she might have a hard time walking on her own. She may be disoriented. You might also notice her bumping into things she usually knows are there.

CBD has become popular in the dog world. Not only has CBD been found to help with seizures, but with pain, sleep, anxiety, skin problems, cancer, and digestive issues, too.

There are 2 Types of Seizures

There are two types of seizures a dog could have; symptomatic or idiopathic.

Symptomatic seizures are caused from an abnormality inside or outside of the brain. This could be from lead poisoning, encephalitis, or some sort of head trauma.

Idiopathic epilepsy doesn’t have a cause, though. Idiopathic epilepsy is thought to be genetic. Dog breeds who are commonly diagnosed with idiopathic epilepsy include English Springer Spaniels, Viszlas, Collies, Beagles, and Dachshunds. If you have one of the dog breeds prone to epilepsy, don’t worry yourself too much but just be sure to keep a watch for symptoms.

What’s the Best Way to Treat Seizures?

The medication that is prescribed to dogs with seizures has been found to help but may also come with heavy side effects including lethargy, long-term liver damage, and/or confusion.

One of the methods dog lovers are turning to instead of pharmaceutical medicine is Cannabidiol, or CBD. CBD oil is a non-toxic, natural, and effective form of treatment (of course, make sure you talk to your vet).

When you’re researching CBD and seizures in dogs, there are hundreds of positive testimonials. But, it comes as no surprise that CBD is met with controversy.

It’s important for you to understand CBD oil doesn’t make your dog ‘high’ like marijuana does. THC is responsible for the ‘high’ effect. And, there is little to no THC found in CBD oil.

If you’re a supporter of the medicinal effects of the cannabis plant, you may be asking why THC is not recommended for dogs. After all, we do recommend medicinal marijuana for humans who are experiencing serious medical conditions.

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The reason. Dogs are extremely sensitive to THC. THC is the primary psychoactive component of a marijuana plant. Cannabidiol (CBD) is one of 113 compounds found in cannabis plants. The compounds, known as Cannabinoids, are natural and don’t contain any psychoactive properties or effects.

CBD with extremely low doses of THC may help dogs with seizures significantly, though. And, it has been found to be particularly helpful to dogs who are experiencing pain from cancer and/or seizures.

Dr. Stephanie McGrath is a veterinarian who specializes in neurology at Colorado State University. She is an advocate for CBD in veterinary medicine and is currently leading a clinical study on the treatment of epilepsy (which causes seizures). You can do your own research about her studies to see what she’s found if you’re interested in learning more about the effects of CBD.

CBD Dosage for Dogs

When you choose to use CBD oil for your dog with seizures, it’s important to start at the lowest dose possible. You can then increase the dosage if necessary.

The dosage of the CBD oil is also a discussion you could have with your veterinarian… especially if your dog is taking any other medications. You want to make sure the CBD oil won’t interact negatively with any medicine you’re dog has been prescribed.

The Side Effects of CBD

When you’re looking for a new medication for your dog, natural or pharmaceutical, you want to know the side effects.

CBD has no known side effects when administered on its own. However, CBD can have interactions with certain prescribed medication by inhibiting a family of liver enzymes, called cytochrome P450. This enzyme metabolizes more than 60 percent of the marketed medications we consume.

You can read more about CBD Drug Interactions on CannaCanine’s website. You’re able to look at a full list of medications metabolized by Cytochrome P450 3A4.

Testimonials Say it All

CannaCanine enjoys sharing testimonials so you’re able to hear real-world experiences about dogs who have used their products. Below, you will read a testimonial from CannaCanine about Blaise, a dog who was experiencing seizures, who had been prescribed pharmaceutical medication for treatment. His owner no longer wanted him to take phenobarbital… so she considered CBD oil. The CBD oil worked wonders on Blaise.

Please note, every dog is different and there’s no guarantee any medication, whether pharmaceutical or natural, will work the same for every dog. But, if you’re looking for alternatives, the research shows CBD oil may be worth considering … especially with the support from your veterinarian.

“Blaise started to experience seizures when he was just a year old. The seizures started to be mild and were few at the start. I thought nothing of it at first because they were so infrequent. When Blaise was around two and a half he started having partial seizures. These affected half of his body and he would suddenly tumble to the ground. This was absolutely horrifying to watch as they came often without warning.

To help combat his seizures I was recommended to give him phenobarbital. Phenobarbital is a common medicine given to dogs to help treat seizures. Several people told me to hold off on the phenobarbital treatments due to the ill side effects on dogs. I decided to wait before starting treatment to see if the seizures would return. By Blaise’s third birthday he finally had a full seizure. My worst fears had finally manifested!

Our vet immediately put Blaise on a high dose of phenobarbital for every 12 hours. Blaise became so drugged up that he would lose his balance and fall over. The worst of it was when he fell down twelve flight of stairs! I hated seeing him like this. His perky and fun personality was gone, replaced by lethargy and sadness. Blaise became a shell of the fun dog he once was.

A a nurse I had read articles on the beneficial effects of CBD oil on seizures. I started to research natural and alternative medicine for canines to learn more about CBD oil. At first I was cautious but decided to try it on Blaise. It was the best decision I could make! I was glad I ordered the CBD treatment. Despite the process of weaning him off of phenobarbital, the first dose of CBD oil made him more alert. Little by little, I got him off the phenobarbital.

Today, Blaise is seizure free and no longer taking phenobarbital. All thanks to CBD oil!”

Chat with Your Vet

I can’t emphasize this enough. Before implementing CBD oil in your dog’s routine, you should talk to your vet. If your dog is struggling with a medical condition, you want to make sure you have the dosage right. And, you also want to ensure your dog is a suitable candidate for CBD use.

If your veterinarian isn’t familiar with alternative medicine, you might consider contacting a veterinarian who specializes in it. You can find an alternative veterinarian by searching the American Holistic Veterinary Medical Association’s website.

CannaCanine is 100 percent organic and non-GMO, two qualities you should search for in any CBD oil to ensure maximum quality. CBD that isn’t organic could contain pesticides and herbicides, resulting in more harm than good for your dog.

CannaCanine only contains two ingredients- organic MCT Coconut Oil and Organic CBD Hemp Oil. This is another factor you should consider when searching for CBD oil for your dog. Generally, the more ingredients there are in the oil, the lower the quality of the oil.

Why is coconut oil included? That’s a great question. Coconut oil increases the absorbency of the CBD oil. And, it can work wonders for our dogs. Coconut oil can help with itchy skin, eczema, cuts, scrapes, wounds, and hot spots. And, on top of all of that, it’s a powerful anti-fungal, anti-bacterial, and anti-viral.

I couldn’t wait to try CBD oil for my dogs after learning all the benefits. And, for a limited time, CannaCanine is offering a special promotion.

This year is the Year of the Dog, and to celebrate, CannaCanine is offering you 30 percent off of your store purchase. If you decide this could be a good option for your dog, use code YEAR to take advantage of the sale.

If you have any questions, I am happy to answer them. Please feel free to contact me via AmberLDrake.org or at [email protected]

If you have any topics you would like discussed, I am open to suggestions here too. I want to make sure I’m answering all your questions.

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