Conclusion: CBD is beneficial for treating certain types of epilepsy.
With a forecasted revenue of over 20 billion by 2024, the CBD market is booming. 1 But what exactly is CBD and how effective is it? We look at 9 proven or possible health benefits of CBD oil.
31% of people taking CBD for other conditions such as anxiety or non-cancer-related pain reported improved sleep with CBD. 8
In a large case series of 72 people, 48 patients (66.7%) reported an improvement in sleep scores within the first month, but these fluctuated over time. 9
In June 2018, the FDA approved Epidiolex (a plant-based formulation of CBD) to treat seizures for people 2 years of age and older with Dravet syndrome and Lennox-Gastaut syndrome (LGS), which are two rare forms of epilepsy.
CBD can interact with other medications used for epilepsy and some serious side effects have been reported, notably, a decrease in liver function when given to people already taking valproate.
CBD oil contains CBD mixed with an inert carrier oil, such as coconut oil or hemp seed oil. The bottled oil, called a tincture, is sold in various concentrations. There are also CBD capsules, CBD gummies, and under-the-tongue CBD sprays.
Remember, because CBD oils are largely unregulated, there is no guarantee that a product is either safe or effective.
Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles. She helped co-author the first integrative geriatrics textbook, "Integrative Geriatric Medicine."
There is some evidence that CBD interacts with seizure medications such as Onfi (clobazam) and boosts their concentration in the blood. Further research is needed.
Part of this response could be explained by the way that CBD acts in the brain. In low doses, CBD may act as an agonist to several receptor sites, meaning it acts similarly to surrounding molecules that normally bind to the receptor, enhancing the signalling of those receptor sites. At higher doses, however, too much activity at the receptor site can lead to an opposite effect, negating the beneficial effects of CBD.
This page is regularly updated, to include the most recently available clinical trial evidence.
Anywho, back to CBD’s main effects. It appears to impact a variety of other receptors in the body, including an important receptor involved in pain and stress response, called TRPV1.    Other receptors that CBD impacts include GPR55, 5HTI-alpha, and adenosine A2A, which variously can help with inflammation, pain, anxiety, and even potentially cancer.    
Like THC, CBD is a compound in cannabis. Unlike THC, CBD won’t get you “high”, but is has shown promise in animal research for the treatment of anxiety, pain, inflammation, cancer, and more. Unfortunately, as of 2021, human trials are still few.
Our evidence-based analysis on cannabidiol (cbd) features 120 unique references to scientific papers.
The main studied benefit to CBD is on two rare forms of epilepsy (Lennox-Gastaut and Dravet syndrome),  but potential benefits stretch from common maladies (anxiety,  chronic pain  ) to reduction in inflammation  , even to potential benefits for cancer.  Human randomized trials are quite scarce, though.
Two reasons. First, isolated CBD won’t get you “high”, unlike THC (the other main cannabinoid in cannabis). Second, isolated CBD has shown a ton of promise in animal research for the treatment of (anxiety, pain, inflammation, cancer, etc). Unfortunately, as of as of 2019, there are relatively few human trials. And unregulated CBD often contains way lower or higher doses than the label states, sometimes even containing unlisted THC. Things are heating up though: in 2018, the FDA approved the first CBD pharmaceutical (Epidiolex ® ) for two rare types of epilepsy. Stay tuned to this page, as nearly 190 trials are underway!