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cbd research uk

Summary:

CBD oil comes as a liquid or in capsules.

What are cannabis and cannabinoids?

The plant produces a resin that contains a number of substances or chemicals. These are called cannabinoids. Cannabinoids can have medicinal effects on the body.
The main cannabinoids are:

There are different types of oil made from parts of the cannabis plant. Some are sold legally in health food stores as a food supplement. Other types of oil are illegal.

You could talk with your cancer specialist about the possibility of joining a clinical trial. Trials can give access to new drugs in a safe and monitored environment.

‘What a giddy array of products there are: from CBD water to cooking or massage oils, pills, chewing gum, transdermal patches, pessaries, gin, beer and lube.’ Photograph: MediaWorldImages/Alamy Stock Photo

But the landmark decision in November 2018 to allow UK doctors to prescribe cannabis under extremely limited circumstances, inspired by the cases of Billy Caldwell and Alfie Dingley, whose epilepsy is improved immeasurably by medicinal cannabis products containing both THC and CBD, has left many in a limbo: knowing or believing that cannabis offers a cure, yet remaining unable to access it.

‘What a giddy array of products there are: from CBD water to cooking or massage oils, pills, chewing gum, transdermal patches, pessaries, gin, beer and lube.’ Photograph: MediaWorldImages/Alamy Stock Photo

R oll up, roll up, ladies and gentleman, and gather around. Do you, your loved one – or family pet – suffer from any of the following conditions? Cancer, epilepsy, diabetes, arthritis, anxiety, menstrual cramps, insomnia, dry skin, psychosis, Alzheimer’s, dementia, anger, depression, ADHD, Crohn’s and IBS, PTSD, opiate addiction, Parkinson’s, pain of any kind, migraine, or canine uptightness? Then it’s your lucky day.

Britain is poorly prepared for the wide-ranging changes to cannabis law that are flowering worldwide. British hemp farmers face serious commercial disadvantage as CBD may be legally extracted only from the stem and leaves of hemp crops, not from the flower, where the cannabinoids are produced in greatest profusion. Most CBD is therefore imported: a wasted opportunity to create and control – and tax – a new industry.

Pain
We aim to test the efficacy and potency of a range of novel cannabinoid related compounds, including those that target receptors such as the cannabinoid receptors CB1 and CB2, and to develop new analgesic treatments for use in the clinic. These novel agents are evaluated using in vitro models of hypersensitivity in cultured neurons from rodent and human sensory ganglia. We have recently shown that Cannabidiol (CBD) at low doses , corresponding to plasma concentrations observed physiologically , inhibits or desensitizes neuronal TRPV1 signalling by inhibiting the adenylyl cyclase – cAMP pathway, which is essential for maintaining TRPV1 phosphorylation and sensitization. CBD also facilitated calcineurin-mediated TRPV1 inhibition. These mechanisms may underlie nociceptor desensitization , and the therapeutic effect of CBD in animal models and patients with acute and chronic pain.

Inflammation & Cancer
We investigate the mechanism of action of cannabinoids and relevant compounds at a molecular level through the study of relevant oncological signalling pathways. We also evaluate the efficacy and interaction of cannabinoids in combination with cytotoxic and immune-modulating therapies for the treatment of cancer.

Summary of current research

Pain
Up to 50% of all cancer patients experience pain, and as many as 90% with advanced cancer live with chronic debilitating pain that can be difficult to treat. The pain contributes significantly to increased morbidity and reduced quality of life, characteri s ed by fatigue, depression, insomnia, and weight loss. The evaluation and development of cannabinoid compounds may lead to novel therapies which provide better pain relief and improve the quality of life in patients with chronic pain conditions.

There are a number of other ongoing translational projects and we welcome industry/academic collaborations to accelerate this process. These include a collaborative protocol for a placebo-controlled double-blind Phase II virtual trial with a pilot & feasibility phase to assess the efficacy and safety of cannabidiol (CBD) for the treatment of home self-isolating health care worker patients with mild COVID-19 .

Inflammation & Cancer
Cannabinoids have shown merits in not only alleviating the unwanted side – effects of cancer treatments but have also displayed promising pre-clinical antitumour properties, through modulating processes which include apoptosis and autophagy. Co-administration of cannabinoids with cytotoxic therapies may enhance the potency of these outcomes . In cancers that are refractory to systemic therapy, t hese synergistic effects warrant further investigation to select combinations for clinical translation and evaluation .