Also known as “cotton mouth,” CBD can potentially cause your mouth and eyes to feel very dry, notes Dr. Brent A. Bauer via Mayo Clinic. Though this side effect is more likely to occur with THC, it can happen with CBD, as well.
In some cases, those who ingest CBD supplements might experience nausea, says Dr. Matharu-Daley. This depends on how sensitive the person is to CBD, as well as the amount they ingest.
Generally speaking, CBD is considered a safe substance when applied topically or taken orally. There are, however, some potential side effects to keep in mind when using this substance, the majority of which are mild.
CBD—the abbreviation for cannabidiol, a substance that’s generally derived from the hemp plant—has skyrocketed in popularity over the last five years. In fact, according to some research, “CBD” as a Google search term remained stable from 2004 to 2014 but has since ballooned by up to 605%.
Some people may get diarrhea or liver problems [when using CBD]. This is dependent on the individual and their medical history, so monitoring is important,” says Dr. Matharu-Daley.
There are, in fact, dozens of cannabinoids, as well as other substances in cannabis sativa.
By acting on the ECS, CBD may have many different effects on the body. Examples include: balancing the body’s overall physical functions (homeostasis), reducing pain sensation, and lessening the body’s reaction to injury or infection (inflammation).
What Is CBD?
The dose of CBD also depends on the form and strength and whether or not it has other active ingredients.
Early research on CBD for the treatment of insomnia suggests that it may be effective. Additional studies are needed.
There are also studies of oral, topical, and inhaled CBD for use in many other conditions including: dystonia (movement disorder), Fragile X syndrome (rare genetic disorder), graft-versus-host disease (bone marrow transplant rejection), multiple sclerosis (MS), opioid withdrawal, schizophrenia, and smoking cessation. CBD is also used to alleviate Parkinson’s symptoms, but there are some studies that advise against it.
CBD oil can interact with certain medications, including some drugs used to treat epilepsy. CBD inhibits an enzyme called cytochrome P450 (CYP450), which metabolizes certain drugs. By interfering with CYP450, CBD may either increase the toxicity or decrease the effectiveness of these drugs.
In June 2018, the U.S. Food and Drug Administration (FDA) approved Epidiolex, a CBD oral solution used for the treatment of certain rare forms of epilepsy in children under 2—Dravet syndrome and Lennox-Gastaut syndrome. Both are exceptionally rare genetic disorders causing lifelong catastrophic seizures that begin during the first year of life.
Part of this response could be explained by the way that CBD acts in the brain. In low doses, CBD may act as an agonist to several receptor sites, meaning it acts similarly to surrounding molecules that normally bind to the receptor, enhancing the signalling of those receptor sites. At higher doses, however, too much activity at the receptor site can lead to an opposite effect, negating the beneficial effects of CBD.
Medical marijuana is frequently prescribed to people with intractable (treatment-resistant) pain, including those with terminal cancer. There is some evidence that CBD contributes to this benefit.
CBD is the short name for cannabidiol, one of the two chemicals—among the dozens in cannabis—that have the most health benefits. The other, tetrahydrocannabinol (THC), produces the psychoactive effects described as being “high.” CBD oil generally does not contain THC, although some trace amounts may be present in products sold in certain states.
CBD shows promise in the treatment of anxiety disorders, suggests a 2015 review of studies in the journal Neurotherapeutics. According to the investigators, CBD demonstrated potent anxiolytic (anxiety-relieving) effects in animal research, albeit with counterintuitive results.
There are no guidelines for the appropriate use of CBD oil. CBD oil is usually delivered sublingually (under the tongue). Most oils are sold in 30-milliliter (mL) bottles with a dropper cap.