The study found that CBD exerted neuroprotective actions and assisted in repairing communication between neurons in the brain. The researchers administered 3mg/kg of CBD per day to mice models with cerebral ischemia — reporting improved motor coordination and neurological scores.
More studies are needed to determine if CBD can be used as monotherapy to manage tremors and other symptoms among the elderly and patients with PD.
Scientists have been examining the health benefits of CBD for quite some time now, with great effort being fueled into research on how CBD may affect tremors.
CBD Oil for Anxiety Tremors
As mentioned, CBD interacts with the ECS, which is a broad system of receptors and neurotransmitters that work to maintain homeostasis between essential bodily functions — including muscle movement.
According to a review of studies evaluating the effects of different CBD doses in clinical populations, an effective dose can range from 1 to 50 milligrams per day. The dosage can be increased when you don’t feel any difference after, say, one week. From there, you can gradually adjust the amount of CBD to the point where it effectively reduces tremors.
So, while temporary tremors aren’t an alarming sign, chronic episodes may indicate a serious disease requiring medical attention.
In 2015, Neurotherapeutics published a study that examined the efficacy of medical cannabis for PD symptoms, concluding that the majority of the subjects showed significant improvements at the end of the treatment .
This is exactly why the IETF is so pleased to support Dr. Handforth and this cutting-edge research with a nearly $20,000 grant. “The significance of this work is two-fold,” says Dr. Handforth. “First, finding that CBD suppresses tremor in an animal model may provide justification for a clinical trial of CBD for essential tremor in humans. Second and more importantly, if we can understand how CBD stops the tremor, what mechanisms are at work, then an ET-specific medication could be developed that would be better-tolerated and more effective than what it available today.”
In this study, Dr. Handforth aimed to show CBD can suppress tremor in animal models. If successful, it would offer justification for further study of CBD in humans. First, the study had to determine what effects CBD would have on mice impacted with harmaline–induced tremor. Then, if reduced, the team had to discover how CBD suppressed the tremor.
Cannabidiol Anti-Tremor Action & Mechanisms – Conclusion
The U.S. Food and Drug Administration (FDA) has not approved cannabis as a treatment for any medical condition. However, the chemical components in cannabis are being studied. It is well known that certain chemicals in cannabis activate specific receptors throughout the body and these chemicals may be useful in treating neurological conditions, like ET. In this study, Dr. Handforth is looking at a specific chemical called Cannabidiol. Cannabidiol (CBD) is one of at least 113 active chemicals (also known as cannabinoids) identified in cannabis. However, CBD does not produce any intoxicating effects or alteration in mood. For years it was thought to be a benign and unimportant part of the plant. Now it is being investigated as a possible treatment option for ET.
Testing a variety of doses, Dr. Handforth was able to note a robust suppression of tremor in the mice given CBD, without the animals showing any signs of impairment or sedation. Next, the team worked to discover what receptors in the brain might be involved in the noted effects. After looking at several options the information suggests that CBD activates the 5HT1a receptors to suppress tremor by activating the TRPV1 receptor.
Principle Investigator: Adrian Handforth, MD
As an interesting aside, one experienced doctor claims that THCV helped a patient with a severe ET case. According to the physician, it was the worst case of essential tremor he had seen in almost 40 years. The patient could hardly walk, write her name, or swallow food.
Essential tremor is a nervous system (neurological) disorder. It is characterized by involuntary and rhythmic shaking, which can occur in any part of the body. It most commonly occurs in the hands when performing simple tasks like drinking from a glass or tying shoelaces.
While there is no medication capable of completely removing the symptoms of essential tremor, some can reduce their severity. In general, doctors prescribe drugs for oral consumption. Some commonly prescribed medications include:
Using CBD for Tremors (Dosage and Use)
However, there was a recent breakthrough for the industry as researchers at the University of California San Diego are currently investigating the effect of cannabinoids on ET. They are conducting a study that will look at the effectiveness and safety of a cannabis formulation for helping ET.
The researchers estimate that approximately sixteen participants with ET will take part in the study. All participants undergo a complete neurological examination and psychological testing as part of the study.
Parts of the Body Affected
Despite how common ET is, there is no cure, and there are currently very few treatment options available.