While there is hope for treating other conditions with the plant extract, Epidiolex remains the only CBD-derived drug approved by the F.D.A. Most of the research on cannabidiol has been in animals, and its current popularity has outpaced science. “We don’t have the 101 course on CBD quite figured out yet,” said Ryan Vandrey, an associate professor of psychiatry and behavioral sciences at Johns Hopkins University School of Medicine.
Dr. Smita Das, chair of the American Psychiatric Association’s Council on Addiction Psychiatry’s cannabis work group, does not recommend CBD for anxiety, PTSD, sleep or depression. With patients turning to these to unproven products, she is worried that they may delay seeking appropriate mental health care: “I’m dually concerned with how exposure to CBD products can lead somebody into continuing to cannabis products.”
A few drops of CBD oil in a mocha or smoothie are not likely to do anything, researchers contend. Doctors say another force may also be at play in people feeling good: the placebo effect. That’s when someone believes a drug is working and symptoms seem to improve.
“It’s promising in a lot of different therapeutic avenues because it’s relatively safe,” said James MacKillop, co-director of McMaster University’s Michael G. DeGroote Center for Medicinal Cannabis Research in Hamilton, Ontario.
Earlier research found fewer than a third of 84 products studied contained the amount of CBD on their labels. Some users of CBD have also failed drug tests when the product contained more THC than indicated.
An analysis in 2015 showed that CBD could reduce social anxiety and stress. It showed that CBD could help with disorders like SAD, panic disorder, post-traumatic stress disorder (PTSD), generalized anxiety disorder, and obsessive-compulsive disorder (OCD).
Although immunomodulatory effects have not been fully proved, certain cannabinoids reduce inflammatory responses at the optimal concentration in patients with autoimmune diseases like arthritis, multiple sclerosis, encephalomyelitis, lupus, and Parkinson’s. CBD is particularly potent in this regard.
In an animal trial done in 2005, low-dose oral cannabinoids helped slow down the progression of atherosclerosis  . Eventually, it was suggested that there was a substantial therapeutic potential for conditions atherosclerosis. Another animal study in 2007 showed that CBD had cardio-protective effects  in case of heart attacks.
14. CBD Can Combat Addiction
CBD has been demonstrated in various studies to have direct interaction with dopamine and serotonin receptors in the brain. Excessive heroin and opioid use damages these receptors and limits the ability of your brain to process psychological, physical, and emotional actions properly.
Researchers tested the efficacy of inhaled CBD on 24 cigarette smokers who wanted to quit smoking in a 2013 study  that lasted a week. Twelve of the participants who received CBD reduced smoking by about 40%, while the group who received a placebo saw no reduction in the number of cigarettes they smoked.
Anyone who has been afflicted with some form of pain has, in one way or another, showed interest in CBD. Cannabidiol is believed to offer potential therapeutic benefits, pain relief being the most prominent.
Most opioids are used to reduce pain and certain mood disorders. CBD helps provide relief for symptoms like chronic pain, anxiety or mood disorders, and other issues we have mentioned above. Hence CBD has been shown to control cravings for opioids and reduce anxiety.
Unfortunately, few human trials investigating the use of CBD as a single agent to relieve pain exist, with most trials using a combination of CBD and THC to relieve pain. Notably, Health Canada has approved a combination medication that contains both THC and CBD in a 1:1 ratio for the relief of central nerve-related pain in multiple sclerosis, and cancer pain that is unresponsive to optimized opioid therapy.
CBD can interact with other medications used for epilepsy and some serious side effects have been reported, notably, a decrease in liver function when given to people already taking valproate.
CBD has also been investigated for use in other forms of treatment-resistant epilepsy, usually in addition to conventional epilepsy medications. Results varied, but several trials showed CBD significantly reduced seizure frequency by almost 44% in most people. 3
Animal studies have shown that CBD has a positive effect on serotonin levels in the brain, and serotonin. Low levels of serotonin are thought to play a key role in mood as well as pain. 11
Beneficial effects on anxiety after taking CBD were reported in an observational study where 21 patients out of 400 had anxiety. 8