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Of the participants, 10 reported becoming seizure free.
However, the study did find seizure intensity increased in patients taking cbd.
Does CBD Interact With Carvedilol (Coreg)?
Cannabidiol (CBD) may potentiate the hypotensive effects of carvedilol — leading to side effects including lightheadedness or confusion. Caution is advised.
Carvedilol is an alpha-1 adrenoreceptor blocker. It’s used in the treatment of hypertension and chronic heart failure.
While the chances these medications will interact is slim, the severity of these conditions makes it especially important for this medication to work as expected. Anything that could interfere with the ability for carvedilol to exert its effects should be avoided — including CBD.
Here’s everything you need to know.
Table of Contents
CBD and carvedilol are unlikely to interact. However, because of the shared effects on blood pressure, this combination isn’t recommended.
Speak to your doctor about using CBD before combining it with any prescription medications.
Does CBD Interact With Carvedilol (Coreg)?
Yes. CBD may interact with carvedilol.
The chances of serious interaction with this combination are low but not impossible. The most concerning side effects revolve around both substances’ ability to reduce blood pressure. Hypotension could result in lightheadedness, confusion, and fainting — all of which can become dangerous in certain situations.
CBD may interact with carvedilol in two ways:
A) CBD Enhances the Effects of Carvedilol on the Body (Agonistic Interaction)
When two items exert the same kind of effect on the body, they become agonists to each other. This causes more potency in their effects. Sometimes more potency of a medication isn’t a good thing.
Carvedilol is used to reduce blood pressure by acting on the alpha-1adrenergic receptors, which relax the blood vessels and reduce peripheral vascular resistance.
CBD, on the other hand, works on the endocannabinoid receptors, which is also involved with a reduction in blood pressure.
Therefore, taking both compounds together could result in a rapid decrease in the blood pressure, causing the user to feel dizzy and faint.
B) CBD May Slow Down Carvedilol’s Metabolism (Metabolic Competition)
Metabolic competition occurs when two or more compounds require the same enzymes for metabolism. They will compete with each other, leading to a slower metabolic rate overall.
Carvedilol gets metabolized by the CYP2D6 enzymes. CBD is metabolized by CYP2D6, too. This means consuming them together could cause them to compete.
The result could be the overaccumulation of one or both drugs in the body, delay in their removal, and increasing the risk of side effects or toxicity.
This could be prevented or lessened to a certain degree by taking the two drugs at different times of the day with enough interval between the two (around 2 hours or more).
Similar Medications: CBD & Alpha Blockers
Carvedilol is classified as both an alpha-blocker as well as a beta-blocker. CBD and alpha-blockers all share similar risks for interaction and side effects.
Here’s a list of similar medications that share a similar level of risk when combined with CBD:
- Doxazosin Mesylate (Cardura)
- Prazosin Hydrochloride (Minipress)
- Terazosin Hydrochloride (Hytrin)
Is It Safe to Take CBD & Carvedilol (Coreg) Together?
A minimum dose of both drugs, taken for a short duration, is less likely to cause many side effects. But the same cannot be said for large doses or for even minimum doses taken for a longer time.
Over long-term use, both drugs could accumulate more than normal in the body — leading to side effects. Some of these side effects can be severe and are worth trying to avoid.
You can minimize the risk further by taking CBD and carvedilol at least 2-hours apart and speaking to your prescribing physician before you begin.
No matter the dosage, you must always consult your medical practitioner before starting these two drugs together. Always be wary of any abnormal side effects, and if you encounter any health issues or side effects while taking these drugs, get medical help immediately.
Is CBD A Viable Alternative to Carvedilol (Coreg)?
CBD has a blood pressure-lowering ability. However, this differs from the mechanism of action of carvedilol and may not be enough for severe cases.
CBD works on the CB1 receptors of the endothelium by releasing nitric oxide that can dilate blood vessels, lowering blood pressure .
CBD has been shown to reduce blood pressure in users who also have increased heart rates .
CBD has antioxidative and anti-inflammatory properties as well , which offers some indirect hypotensive effects by combating inflammation in the arterial system.
CBD may be a good alternative for reducing blood pressure in mild cases, such as prehypertension. However, it may not be sufficient for people diagnosed with high blood pressure.
What is Carvedilol (Coreg)?
Carvedilol is an antihypertensive belonging to the alpha-blockers class. It has properties of both alpha-1 adrenoreceptor blocker and beta-adrenoceptor blocker. Coreg is one of its most commonly used brands.
Carvedilol is used in the treatment of hypertension, mild to severe chronic heart failure, hypertension, and left ventricular dysfunction.
It’s an FDA-approved drug and sold as a prescription-only drug in most countries.
Carvedilol (Coreg) Specs:
|Trade Name||Coreg, Caditone, Cadmos, Carca, Carca-CR, Cardivas, Cardivas, Carelol, Carloc, Carzec, Caslot|
|Classification||Alpha-Blockers, Beta-adrenoceptor blocker|
|Interaction With CBD||Agonistic, Metabolic competition|
|Risk of Interaction||Moderate|
Other Names For Carvedilol (Coreg)
Carvedilol is sold under many different names. All share the same risk and potential interactions.
Other names for Carvedilol include:
What Does Carvedilol (Coreg) Do?
Carvedilol is used in the treatment of coronary heart failure, left ventricular dysfunction following myocardial infarction, and hypertension.
It’s an alpha-1 adrenoceptor blocker that also possesses the properties of a beta-adrenoceptor blocker. This is attributed to its two forms, the S(-) enantiomer and the R(+) enantiomer. Its S(-) enantiomer is a beta-adrenoceptor blocker, and the R(+) enantiomer has both forms of beta and alpha-1 adrenoceptor blocker.
The double ability of carvedilol can decrease side effects while using low-dose combination drugs in comparison to a single heavy dose of one drug.
Carvedilol can decrease rapid or increased heart rate through beta-adrenergic antagonism, and it can lower blood pressure through alpha-1 adrenergic antagonism. Carvedilol can act on alpha-1 adrenergic receptors and relax the smooth muscle in the vasculature. This causes a reduction in peripheral vascular resistance, which leads to an overall reduction in blood pressure.
It has a long duration of action and should not be stopped abruptly as it may exacerbate coronary artery disease.
At high doses, it may even be able to block calcium channels. It also has antioxidant properties, which can prevent oxidation of low-density lipoprotein and its uptake into coronary circulation.
Carvedilol has a half-life of 4 to 7 hours, and it reaches peak concentration at 4 to 7 hours. Carvedilol can cause defects in the newborn if used during pregnancy, and there is no information about its effects on lactation.
Side Effects of Carvedilol (Coreg)
- Atrioventricular block
- Chest pain
- Decrease in heart rate
- Raynaud phenomenon
- Skin rash
- Increased sleepiness
- Weight gain
Key Takeaways: Is it Safe to Take Carvedilol (Coreg) With CBD?
CBD and carvedilol carry a mild to moderate risk of interaction with each other. The main concern is that CBD may cause blood pressure to drop too low when used in combination with prescription antihypertensives like carvedilol. Side effects of this would involve dizziness, confusion, and fainting. These side effects can be dangerous while driving, operating heavy machinery, or moving up or down stairs.
It’s always wise to speak with your doctor before taking supplements alongside prescription medications.
You can also further minimize the risk of side effects by separating the dose of carvedilol and CBD by 2 hours.
Can I Take CBD Hemp Oil With Carvedilol?
In the United States, adding CBD to food or calling it a dietary supplement is unlawful. Also, while the FDA has approved a few CBD medications to treat specific ailments, Lundgren cautions that CBD supplied over-the-counter will not be safe or beneficial for heart failure.
CBD oil, on the other hand, may not have the same characteristics, and it might also produce gastrointestinal problems such as diarrhea or a loss of appetite. He warns that CBD products may contain unknown substances and may not be appropriately labeled.
Your liver breaks down CBD oil when you use it. It may conflict with your heart failure or other heart problems medications throughout this process. Warfarin, some statins, calcium channel blockers, beta-blockers, and nitrates are all known to interact with CBD. Just because a supplement is natural, does not indicate it is safe, according to Lundgren.
Is hemp oil compatible with blood pressure medications?
People with high blood pressure may be prescribed drugs by their doctors. If someone is on blood pressure medicine and using CBD products, they should inform their doctor.
What does the research say?
CBD products have been shown in several trials to help decrease blood pressure.
CBD may have vasodilatory benefits in human and rat arteries, according to a 2020 study. CBD may enhance blood flow by widening blood arteries, according to the scientists.
A 2017 study also looked at the effects of a single dose of CBD oil on healthy people. The authors discovered that it reduced blood pressure in both healthy and stressed people.
Stress, according to the American Institute of Stress, can raise blood pressure. Stress hormones constrict the blood arteries, causing the heart to beat quicker.
More research is needed, however, to assess the effect of CBD on cardiovascular diseases.
Risks of CBD
According to the Food and Drug Administration (FDA), there may be certain dangers associated with utilizing CBD products. Some examples are:
- If the person is taking drugs to address anxiety, stress, or sleep issues, they may experience sleepiness or sedation.
According to a 2017 study, consuming CBD with antihypertensive drugs can cause either substance’s blood concentration to alter. If someone takes CBD and blood pressure medicine, they should tell their doctor.
CBD and pregnancy
The FDA advises against using CBD products when pregnant or breastfeeding.
The effects of CBD on a growing fetus have not been thoroughly studied. There is some indication, however, that excessive dosages of CBD in pregnant test animals may impair the reproductive system of a male fetus.
However, a study conducted in 2021 on the effects of CBD on pregnant mice indicated that daily CBD doses were unlikely to accrue in the mice and their fetuses.
More research is needed to determine the potential dangers of CBD consumption during pregnancy.
Which drugs should be avoided when using hemp oil?
The same wide family of liver enzymes known as CYP450 breaks down a large number of medicines, including CBD.
Some enzymes in this family are inhibited by CBD. This causes patients to break down certain pharmaceuticals more slowly, increasing the risk of side effects unless your doctor lowers the amount. CBD, on the other hand, activates other enzymes in this family, speeding up the breakdown of certain medications and making them less effective unless the dose is raised.
When CBD is used with these medicines, for example, you may have more negative effects:
“A lot of questions remain concerning how CBD interacts with the body’s drug-metabolizing enzymes.” “We know that CBD affects some drug-metabolizing enzymes, but not others, and there are many more about which we don’t currently have any information,” explains Dr. Bemben.
Can CBD oil be used by heart patients?
CBD does not cause heart problems on its own. The liver, on the other hand, breaks down and metabolizes CBD. It’s possible that this approach will interact with any heart drugs you’re taking. This could cause difficulties with your liver or interfere with the effectiveness of any drugs you’re taking.
Which drugs interact with CBD oil?
Cannabidiol (CBD)-containing products are all the rage these days, promising help from anything from insomnia to hot flashes to chronic pain and seizures. Some of these statements are true, while others are just marketing fluff. But what harm can it do to try? Not so soon, though. CBD is a physiologically active molecule with the potential for unexpected consequences. There are recognized CBD adverse effects, as well as unintentional interactions with supplements, herbal products, and OTC and prescription drugs.
Doubling up on side effects
While CBD is usually thought to be harmless, it can produce drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare cases, liver damage. When CBD is used with other drugs that have similar side effects, the risk of unpleasant symptoms or toxicity increases. To put it another way, mixing CBD with OTC or prescription sleep medications and substances like opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol can lead to increased sleepiness, fatigue, and possibly accidental falls and accidents while driving. Certain herbal supplements, such as kava, melatonin, and St. John’s wort, might cause increased sedation and lethargy. CBD combined with stimulants (such as Adderall) may cause a decrease in appetite, whereas CBD combined with the diabetes medication metformin or some heartburn medications (such as Prilosec) may cause diarrhea.
CBD can alter the effects of other drugs
CBD may compete for or interact with enzymes in the liver that break down many medications, resulting in too much or too little of the drug in the body, known as altered concentration. As a result of the changing concentration, the medicine may stop working or cause more negative effects. Drug interactions are notoriously difficult to predict, yet they can result in unpleasant and occasionally fatal consequences.
- Clobazam, lamotrigine, and valproate are some of the drugs used to treat seizures.
While the list can be used to identify potential drug interactions with marijuana or CBD oil, the researchers cautioned that plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned) and may contain many other compounds that can increase the risk of unintended drug interactions.
Does the form of CBD matter?
Absolutely. Inhaled CBD has the highest absorption rate, reaching high concentrations in the blood within 30 minutes and raising the risk of acute negative effects. Edibles take longer to absorb and are less likely to induce a high concentration peak, though they may eventually reach levels high enough to cause problems or interact with other drugs. Although there is very little evidence on how much CBD eventually gets into the blood, topical formulations such as creams and lotions may not absorb and get into the blood in significant amounts to interfere with other drugs. The fact that none of these items are regulated or tested for purity, concentration, or safety adds to the confusion.
The bottom line: Talk to your doctor or pharmacist if using or considering CBD
Many other products, including over-the-counter pharmaceuticals, herbal remedies, and prescription prescriptions, may interact with CBD. Some medications should never be used with CBD, while other medications may need to be altered or lowered to avoid serious complications. Many other factors, such as the dose of CBD, the dose of another medication, and a person’s underlying health condition, influence the outcomes of drug interactions. Because they commonly take many drugs, and because of age-related physiological changes that alter how our bodies process medications, older persons are more vulnerable to drug interactions.
People considering or using CBD products should always consult their doctor before doing so, especially if they are taking other medications or have underlying medical conditions like liver disease, kidney disease, epilepsy, heart problems, a weakened immune system, or are taking medications that can weaken the immune system (such as cancer medications). A pharmacist can assist you in learning about a possible interaction with a supplement, herbal product (many of which have their own drug interactions), or over-the-counter or prescription medication. Don’t think that because something is natural that it is safe and that attempting it won’t harm you. It’s a possibility.
Is CBD compatible with statins?
Covid-19 Travel Insurance Plans at Their Finest. CBD is a “potent inhibitor” of two enzymes (CYP3A4 and CYP2D6) that impact several popular medicines, including antihistamines, benzodiazepines, antidepressants, and statins, according to study.
Is CBD oil compatible with blood thinners?
Warfarin and CBD oil should not be combined. Taking CBD in any form while your warfarin treatment should also be avoided.
Warfarin is an anticoagulant (blood thinner) that prevents hazardous blood clots from forming, which can lead to heart attacks or strokes. Coumadin, Jantoven, and other brand names for warfarin are available.
Warfarin comes with a number of hazards, including severe bleeding, migraines, edema, and acute pain in the limbs.
CBD improved the effects of blood-thinning medications like warfarin by slowing down how the body metabolizes the molecule, according to a 2017 study published in Epilepsy & Behavior Case Reports. By increasing the duration of warfarin in the body, CBD may potentially enhance some of the hazards.
If you’re on warfarin and wish to utilize CBD for another ailment, talk to your doctor first.
Is CBD oil suitable for senior citizens?
No. CBD produces no euphoria. However, tiny levels of THC may still be present in CBD, potentially influencing a drug test.
You may also be consuming enough THC to induce a “high” if you take a large enough quantity of a powerful full-spectrum product.
Should older adults take CBD?
Many people, including seniors, utilize CBD to relieve pain and suffering caused by common conditions such as joint pain, overall pain management, anxiety, and depression.
What drugs shouldn’t be taken with CBD?
A decent rule of thumb is that drugs with a grapefruit warning aren’t usually safe to take with CBD. Before taking CBD, consult your doctor or pharmacist.
Is CBD oil a blood thinner?
Cannabidiol (CBD) is frequently discussed in the media, and it may be recommended as a supplement for your post-workout smoothie or morning coffee. A CBD-infused sports bra is also available. But what is CBD, exactly? What makes it so popular?
How is cannabidiol different from marijuana, cannabis and hemp?
Cannabidiol, or CBD, is the second most common active component in cannabis (marijuana). While CBD is an important component of medicinal marijuana, it is either extracted directly from the hemp plant, a relative of marijuana, or synthesized in a lab. CBD is one of hundreds of components in marijuana that does not produce a “high.” According to the World Health Organization’s report, “CBD has no effects in humans that suggest it could be abused or become addictive…. There has been no indication of public health issues linked to the usage of pure CBD to yet.”
Is cannabidiol legal?
CBD is widely available in most parts of the United States, despite the fact that its legal status is unclear. CBD is legal in all 50 states, with different degrees of restrictions. The FDA relaxed regulatory criteria in December 2015, allowing researchers to undertake CBD experiments. The Farm Bill of 2018 makes hemp legal in the US, making it nearly hard to keep CBD illegal – it’d be like making oranges legal but keeping orange juice prohibited.
All hemp-derived products, including CBD, were removed from the Controlled Substances Act, which makes drug possession illegal. In other words, CBD is lawful if it originates from hemp, but not from cannabis (marijuana) despite the fact that they are the same molecule. Many people currently buy CBD online without having a medical marijuana card, which is allowed in most states.
The evidence for cannabidiol health benefits
CBD has been praised for a range of health conditions, but the greatest scientific evidence is for its usefulness in treating some of the most severe childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which do not respond to antiseizure drugs. CBD has been shown in multiple trials to lessen the amount of seizures and, in some circumstances, to completely eliminate them. Epidiolex, a CBD-based drug, is the first FDA-approved cannabis-derived medicine for these disorders.
- Anxiety studies and clinical trials are looking at the widely held belief that CBD can help with anxiety.
- Insomnia. CBD has been shown in studies to aid in both falling and staying asleep.
- Chronic discomfort. More human research are needed to back up claims that CBD can aid with pain management. CBD may help reduce pain and inflammation associated with arthritis when applied to the skin, according to a study published in the European Journal of Pain. CBD has also been shown to decrease inflammatory and neuropathic pain, both of which are difficult to treat.
- Addiction. According to certain human study, CBD can help reduce cravings for tobacco and heroin in some circumstances. It may also help reduce cravings for alcohol, cannabis, opioids, and stimulants in animal models of addiction.
Is CBD safe?
CBD can cause nausea, tiredness, and irritability as side effects. CBD competes for the liver enzymes that break down blood thinners and other medications, causing them to accumulate in your blood. Certain drugs react similarly to grapefruit.
High-dose CBD users may experience anomalies in liver-related blood tests. Many over-the-counter medications, such as acetaminophen (Tylenol), have a similar effect. If you use CBD on a regular basis, you should inform your doctor.
CBD is generally marketed and sold as a supplement, not a pharmaceutical, which raises serious safety concerns. The FDA does not currently oversee dietary supplement safety and purity. As a result, you can’t be certain that the product you buy contains active chemicals in the dose specified on the label. Furthermore, the product may include unknown components. We also have no idea what the best effective CBD therapeutic dose is for any given medical condition.
How can CBD be taken?
CBD is available in a variety of forms, including oils, extracts, capsules, patches, vapes, and topical skin preparations. A topical CBD-infused oil, lotion, or cream or even a bath bomb may be the best option for reducing inflammation and relieving muscle and joint pain. CBD can also be absorbed directly into the bloodstream using a CBC patch, tincture, or spray that is put under the tongue.
Outside of the United States, the prescription medicine Sativex, which contains CBD as an active component, is approved for multiple sclerosis muscular stiffness and cancer pain. Epidiolex is approved in the United States for specific kinds of epilepsy and tuberous sclerosis.
The bottom line on cannabidiol
Some CBD manufacturers have come under fire from the FDA for making outlandish claims such CBD being a cancer treatment or COVID-19, which it is not. More research is needed, but CBD could be a useful and generally non-toxic option for treating anxiety, sleeplessness, and chronic pain. We can’t estimate beneficial amounts without enough high-quality information from human research, and because CBD is currently available as an unregulated supplement, it’s difficult to know exactly what you’re getting.
If you decide to try CBD, make sure you purchase it from a trustworthy source. Also, check with your doctor to be sure it won’t interfere with any other medications you’re taking.
What are the disadvantages of CBD oil?
Though it’s frequently well-tolerated, CBD might induce adverse effects, such as dry mouth, diarrhea, reduced appetite, tiredness and exhaustion. Other medications you’re taking, such as blood thinners, may interact with CBD. Another source of concern is the unreliability of CBD product purity and dosage.