No, it is not a good idea to take CBD with Xanax. It is recommended not to take Xanax with anything that can cause dizziness. Taking CBD and Xanax together can have health consequences. Read this article before mixing the two to avoid any unwanted side effects. CBD Drug Interactions: How does CBD interact with tranquilizers such as alprazolam (Xanax)? Learn more information on CBD and its potential interaction with benzodiazepines.
Can I take CBD together with Xanax?
I’ve been on Xanax for a while now and want to know if I could also start incorporating CBD into my life. Are there potential drug-drug interactions between CBD and Xanax and how long should I wait in between doses?
Joel Taylor (Thursday, August 05, 2021):
It’s definitely not advised to take CBD oil together with Xanax or any other benzodiazepines. There are interactions between CBD and Xanax as CBD inhibits the enzyme in the liver that metabolises benzodiazepines (and many other drugs for that matter), and so could result in a greater amount of Xanax present in your bloodstream and therefore more side effects, such as: Drowsiness Dizziness Loss of coordination Slurred speech And others.
Avik Das (Thursday, August 05, 2021):
No, it is not a good idea to take CBD with Xanax. It is recommended not to take Xanax with anything that can cause dizziness. Even though it is rare to have drowsiness due to CBD, it is still best to avoid it. Mixing them together might cause adverse side effects of Xanax such as sleeping issues, dizziness, tiredness, and many more.
CBD and Xanax: Can You Take Them Together?
Xanax is one of the most commonly prescribed drugs for anxiety.
With the rising popularity of CBD, many people are now asking, “can I take CBD with Xanax?”.
The answer depends on your dose, the form of CBD you are taking, and your overall health. CBD can potentially interact with other drugs to cause serious health consequences.
Make sure you read this article before you attempt to mix Xanax and CBD.
What is Xanax?
Xanax, known by its proprietary name as alprazolam, is a prescription drug used to treat anxiety and panic disorders. Xanax belongs to a class of medications called benzodiazepines. It comes in immediate-release tablets, which are used for rapid calming effects. People with panic disorder are often prescribed extended-release tablets, which are slowly released into the bloodstream.
Xanax is meant to be prescribed as a short-term solution for anxiety, but many people end up taking it much longer than is recommended.
How Does Xanax Work?
Xanax attaches to two benzodiazepine receptors in your brain and a nervous system called BNZ1 and BNZ2.
The BNZ1 receptor regulates sleep, and BZN2 influences muscle relaxation, memory, anticonvulsant activity, and coordination.
The binding activity of Xanax causes a calming effect on the body by boosting the activity of a chemical called gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter, which means it reduces activity in your central nervous system. This results in relaxed muscles reduced anxiety, and may also cause drowsiness.
Xanax is taken orally and metabolized in the liver by an enzyme called P4503A4.
The recommended dosage varies depending on the person and the condition being treated. In general, the recommended dosage begins at 0.25 mg daily up to a maximum of 4 mg daily. Any daily dose of over 0.75 mg is associated with an increased risk of side effects and addiction.
Xanax and Benzodiazepine Addiction
Xanax is considered one of the most addictive benzodiazepines on the market. Approximately 40% of people who use benzodiazepines daily for a period of six weeks or more will become dependent on them.
This medication has a high potential for addiction and misuse due to its unique properties. It is extremely potent and rapidly metabolized with a short half-life. This means that people are more likely to get withdrawal symptoms and crave more of the drug.
Xanax also uniquely affects dopamine function and the brain’s reward system, similar to many stimulant drugs. As a result, people are more likely to seek out the drug for that surge of feel-good chemicals. This drug-seeking behavior is common among addictive substances.
CBD & Xanax
CBD, or cannabidiol, is a natural health-promoting compound. Among its many benefits, it has considerable potential to treat various anxiety disorders (4). Its benefits are primarily due to its interaction with the endocannabinoid system. Although CBD is considered a very safe drug, it can potentially cause problems when taken with Xanax due to its action on the P450 enzyme in the liver.
As a result, CBD and Xanax may not mix so well.
How Does CBD Interact with Xanax and Other Benzodiazepines?
CBD oil is a strong inhibitor of P450 enzymes, which are the main enzymes that break down benzodiazepines and other drugs. When you take CBD oil, it binds to these enzymes, which can interfere with the way the drugs are metabolized in your body. Simply put, CBD oil can prevent your body from effectively breaking down drugs like benzodiazepines.
The main result of this interference is an elevated level of the drugs in your system. As the amount of Xanax in your bloodstream goes up, it causes unwanted side effects like excessive drowsiness, disorientation, and an increased risk of addiction. These side effects get especially dangerous if you also add alcohol to the mix.
You should never mix alcohol with CBD and benzodiazepines.
What is a Safe CBD Dosage with Xanax?
There hasn’t been much research yet to determine what is considered a safe dose of CBD when taking it with drugs like Xanax. A 2013 clinical study using a CBD sublingual spray found that there were no interactions with liver enzymes with doses up to 40 mg (6). However, more work is needed to look at CBD in forms such as full-spectrum oil, vape, and smoked herbal flowers. All of these forms of administration are metabolized by the liver and therefore carry some risk of interactions.
You can safely use topical CBD with other drugs since topical CBD does not get in your bloodstream and will not inhibit P450 enzymes.
Taking CBD & Xanax Together
There is always a risk of increased side effects when you take CBD and Xanax together. You can reduce this risk by lowering your dosage or spacing out your dosing schedule (i.e., CBD in the morning and Xanax at night). The speed at which your body metabolizes CBD will vary depending on factors like the form of administration and dose. In general, you should wait at least three hours after taking CBD before taking a medication like Xanax.
CBD vs Xanax: Can CBD Replace Xanax?
Due to the high risk of addiction and multiple side effects of Xanax, you may be interested in replacing your Xanax prescription with CBD. Xanax is a very potent anti-anxiety medication that comes with a lot of risks. CBD has less dramatic effects on anxiety reduction but comes with many health-promoting benefits.
Benefits of Xanax
- Powerful calming effects
- Works rapidly
Side-Effects and Risks of Xanax
- Tolerance-forming (you need a higher dose over time for the same benefits)
- Severe withdrawal (i.e., suicidal ideation, depression, hallucinations, confusion, seizures)
- Slurred speech
- Drowsiness and dizziness
- Impaired memory
- Poor balance and coordination
- Trouble focusing
- Very dangerous when mixed with alcohol
- Sleep disturbances (reduced slow-wave sleep)
Benefits of CBD
- Non-habit forming
- All-natural and plant-based
- Does not diminish performance
- Improves heart health (10)
- Reduces inflammation
- Promotes overall wellness
Side-Effects and Risks of CBD
- Dry mouth
- Low blood pressure
How Does CBD Help With Anxiety?
CBD carries a host of anxiety-reducing benefits without interfering with your daily functioning. It helps manage issues like seizures, pain, acne, and anxiety. Additionally, it is neuroprotective, meaning CBD may help prevent age-related decline and improve brain functioning (13).
CBD works by influencing our endocannabinoid system, which helps us maintain a state of internal balance.
Ingesting CBD slows the rate at which your body absorbs an endocannabinoid known as anandamide. This compound, nicknamed “the bliss molecule,” has a calming effect on the nervous system (14).
Ongoing research has found that CBD may reduce anxiety by altering the blood flow in areas of the brain associated with fear and stress. CBD is also linked to serotonin levels by affecting how your brain responds to serotonin. Serotonin is a key neurotransmitter that regulates various functions, including mood.
CBD has been shown to have stress-reducing effects in various populations and across a wide range of health conditions (17).
CBD Dosage for Anxiety
The Federal Drug Administration does not regulate CBD, so you should always be diligent when selecting a source. Always buy your product from a reputable company that offers organic CBD. Look for companies that offer third-party testing to make sure that the product is accurately labeled and dosed. Start with 5–10 mg per day for anxiety reduction and increase your dose by 5 mg a day to find your sweet spot.
Can CBD Help with Xanax Addiction?
CBD is not only useful for anxiety; it may also help curb substance addiction.
A study done on mice displaying drug addiction showed that daily CBD reduced addictive behaviors for five months. These results are pretty exciting, but more work is needed to see how they translate to humans with addiction. Scientists believe that CBD can help people battle addiction by improving brain architecture and reducing symptoms of anxiety (19).
It remains to be seen how well CBD can help someone kick a Xanax addiction. Addiction is a complicated problem. What we do know is that CBD is a very safe alternative to Xanax and has many health benefits beyond anxiety reduction.
If you are interested in tapering off of your Xanax, you should always do so under the guidance of a medical professional.
Taking CBD & Xanax: Final Thoughts
Due to the many health benefits of CBD and the side-effects of Xanax, many people are considering switching to CBD to manage their anxiety. Talk to your doctor if you plan on making the switch so they can monitor any withdrawal symptoms.
Xanax is a popular medication, but it comes with a lot of risks. If you are considering mixing CBD and Xanax, you should avoid it due to potential drug interactions. In order to reduce unwanted side effects, try spacing out your doses so that your body has time to metabolize one drug before you consume the other.
CBD may be able to help people who struggle with addiction to Xanax, but we’ll have to wait and see what the research says.
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- Maroon, J., & Bost, J. (2018). Review of the neurological benefits of phytocannabinoids. Surgical neurology international, 9, 91.
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- De Gregorio, D., McLaughlin, R. J., Posa, L., Ochoa-Sanchez, R., Enns, J., Lopez-Canul, M., Aboud, M., Maione, S., Comai, S., & Gobbi, G. (2019). Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Pain, 160(1), 136–150.
- Crippa, J. A., Guimarães, F. S., Campos, A. C., & Zuardi, A. W. (2018). Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. Frontiers in immunology, 9, 2009.
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Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.
Does CBD Interact With Alprazolam (Xanax)?
Information on risks & possible interactions between CBD & alprazolam.
The use of CBD is gaining rapid momentum because of its safety and effectiveness in treating a host of medical conditions, including anxiety and insomnia.
This has many wondering whether CBD is safe to use with the common anti-anxiety medication, alprazolam (Xanax), and whether CBD is a safer alternative or not.
Here, we’ll explore the potential drug interactions between CBD and alprazolam.
Table of Contents
Does CBD Interact With Alprazolam (Xanax)?
When used in conjunction with psychotropic medicines like alprazolam (Xanax), CBD may cause moderate to severe risk of negative interactions or side effects.
The main issue with this combination is that CBD interferes or slows the metabolism of alprazolam, thus increasing the chances for side effects to occur.
1. Slowed Elimination (Metabolic Inhibition)
Drug metabolism is the process of breaking down the drugs inside the body via various enzymes, mainly for the ease of excretion. A family of liver enzymes called cytochrome P450 is responsible for the metabolism of most of the drugs in the human body. Alprazolam is extensively metabolized and eliminated via cytochrome P4503A4 (CYP3A4).
Studies have concluded that CBD most potently inhibits the CYP3A4 system of enzymes . Most interactions with alprazolam are with drugs that inhibit or induce CYP3A4.
Compounds that are potent inhibitors of CYP3A tend to increase plasma alprazolam concentrations. Drugs that inhibit this metabolic pathway may have a profound effect on the clearance of alprazolam.
Without proper metabolism, a drug may remain in the system longer than is necessary and cause unintended adverse effects.
CBD is also metabolized by the same sets of enzymes as alprazolam. Hence, CBD may compete for or interfere with these enzymes, leading to an altered concentration of alprazolam in the body. Such an interaction is called metabolic competition. It is the most common type of interaction between CBD and other medications.
2. Increased Effect (Agonistic Interaction)
When CBD is consumed together with alprazolam (Xanax), these drugs enhance each other’s actions. This combination can result in a marked increase in the final effects of these medicines that can be more harmful than beneficial.
An agonistic interaction occurs when two or more substances exhibit the same effect on the body. These substances might act on the same or different receptors, but they produce certain effects in the same direction when consumed together.
CBD and alprazolam may exhibit compounded effects towards the sedative, muscle-relaxant, and hypotensive effects. Both substances exert a similar influence in these areas and may cause side effects from causing too strong of a push in this direction.
Side effects of this interaction would include dizziness, lightheadedness, fatigue, and fainting.
Patients need to exercise caution and should only take these medicines together under the close monitoring of a physician.
List of Alprazolam Trade Names
Alprazolam is sold under many different names. All share the same risk and potential interactions.
Other names for alprazolam include:
Alprazolam is classified as a benzodiazepine. CBD and benzodiazepines all share similar risks for interaction and side effects.
Here’s a list of similar medications that share a similar level of risk when combined with CBD:
- Chlordiazepoxide (Librium)
- Clonazepam (Klonopin)
- Clorazepate (Tranxene)
- Diazepam (Valium)
- Estazolam (Prosom)
- Flurazepam (Dalmane)
- Lorazepam (Ativan)
- Midazolam (Versed)
- Oxazepam (Serax)
- Temazepam (Restoril)
- Triazolam (Halcion)
- Quazepam (Doral)
Is It Safe to Take CBD & Alprazolam (Xanax) Together?
Low doses of CBD are generally considered safe to use with alprazolam (Xanax). However, you should always speak with your prescribing physician about combining CBD or any supplements alongside alprazolam. Other factors or medications could contraindicate the use of CBD.
It’s also not a good idea to use large doses of CBD, THC, or other cannabinoids alongside alprazolam or other benzodiazepines.
Side effects are compounded to dangerous levels if alcohol is used in combination with CBD and alprazolam.
Hence, one must exercise extreme caution while consuming these medicines together. It may alter the concentrations of benzodiazepines and influence either safety or efficacy. It is mandatory to consult a trained physician if anyone seeks to combine or replace alprazolam with CBD.
Is CBD a Viable Alternative to Alprazolam (Xanax)?
CBD carries a host of anti-anxiety benefits without interfering with the patient’s well-being and daily functioning as it is both non-intoxicating and non-psychoactive. Hence, patients are keen to use CBD to treat various disorders like seizures, schizophrenia, anxiety, cancer, chronic pain, and inflammation as a natural alternative and adjunct to other pharmaceutical medicines.
It restores the balance of the endocannabinoid system (ECS) by interacting with cannabinoid (CB) receptors throughout the human body. CBD might be effective and safe in treating conditions such as anxiety and panic disorders with fewer side effects than benzodiazepines [2, 3].
Hence, it is tempting to replace traditional anxiolytics with CBD to beat the blues. However, stopping anxiolytics like alprazolam abruptly can result in withdrawal. Alprazolam, like other benzodiazepines, can result in drug dependence even when used within the prescribed doses for a short time.
When alprazolam (Xanax) is stopped suddenly, several systems of the body get affected. Blood pressure, temperature, respiration, and heart rate may increase rapidly. Seizures that can result in coma and even death may also occur.
Some of the physical warning signs of alprazolam withdrawal include:
- Blurred vision
- Myalgia and tremors
- Tension in the jaw and/or toothache
- Numbness and Tingling in the fingers, arms, and legs
- Photosensitivity/ Sensitivity to sound
- Altered sense of smell
- Loss of appetite
- Heart palpitations
- Sweating and/or fever
Some of the psychological symptoms of alprazolam withdrawal are:
- Thoughts of suicide
- Inability to control emotions
- Short-term memory loss
- Mood swings
- Trouble concentrating
Hence, one must be extremely cautious before combining or replacing alprazolam with CBD. Whether by decreasing the dose of alprazolam or spacing the two medications, a trained physician will be able to devise the most appropriate way to include CBD in the treatment regime.
Patients should discuss in detail their reason to make such a change with their doctors. After understanding your health condition and evaluating the safety and effectiveness, a doctor will guide you on the best possible method to incorporate such natural anxiolytics either as an alternative or an adjunct to your current medications.
Alprazolam may need to be tapered gradually over several days or weeks to minimize the side effects and suffering of the patient. A physician with adequate knowledge of the use of CBD and alprazolam in the treatment of anxiety/panic disorder will be able to advise you on the right way of making the shift.
What Is Alprazolam (Xanax)?
Alprazolam (Xanax) is a prescription medicine of the class “triazolobenzodiazepines.”
It’s the most commonly prescribed psychotropic medication for the treatment of anxiety and panic disorders.
Alprazolam is a schedule IV controlled substance in the USA. Alprazolam, like other benzodiazepines, works by enhancing the activity of GABA, a natural chemical compound in the human body.
Alprazolam (Xanax) Specs:
|Trade Name||Xanax, Xanax XR, Niravam|
|Interaction with CBD||Metabolic inhibition|
|Risk of Interaction||Moderate|
What Does Alprazolam (Xanax) Do?
Alprazolam (Xanax) is a highly potent triazolobenzodiazepine indicated in the treatment of anxiety and panic disorders. It is also used as an adjunct to other treatment modalities to treat chemotherapy-induced nausea and vomiting.
Some of the off-the-label uses of alprazolam include reducing the aches, irritability, and tension of premenstrual syndrome. Alprazolam binds two benzodiazepine receptors in the central nervous system, BNZ1 and BNZ2, respectively.
The BNZ1 receptor is responsible for sleep regulation, while BZN2 is mainly concerned with muscle relaxation, memory, anticonvulsant activity, and coordination.
The binding activity of alprazolam causes a calming effect on the body by increasing the action of a chemical called gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter, which means it slows down neuronal activity in the central nervous system. This results in reduced anxiousness and muscle relaxation and can also cause drowsiness.
What Are the Side Effects of Alprazolam (Xanax)?
Alprazolam (Xanax) has many potential side effects. Most of them are mild, but a few can become pretty severe. Side effects become more common with higher doses or long-term use.
The potential side effects of alprazolam include:
- Blurred vision
- Changes in libido
- Constipation or diarrhea
- Dry mouth
- Increased Salivation
- Insomnia/Dream abnormalities
- Memory impairment
- Muscle tone disorder
- Nasal congestion
- Weight gain or loss
These side effects generally appear at the beginning of the treatment and are short-lived and self-resolving. However, some symptoms might linger for a longer period.
Additionally, some rare but serious effects may occur following the consumption of alprazolam, such as:
- Mental changes (such as hallucinations, thoughts of suicide)
- Yellowing of eyes or skin
- Severe allergies
- Severe lapses in memory
Precautions While Taking Alprazolam (Xanax)
The following issues need to be discussed with the treating physician while consuming alprazolam (Xanax) for your health condition:
Concomitant Use With Opioids
When alprazolam is used with opioid drugs, it might cause potentially fatal respiratory depression and sedation. These medicines shouldn’t be used concomitantly unless supervised by a health care provider. Patients shouldn’t drive or operate heavy machinery until the effects of this combination have been determined.
Patients should avoid consumption of any alcoholic beverages as it might lead to fatal interactions.
If the patient is on or plans to take any prescription or over-the-counter drugs, it must be discussed with their physician due to the risk of potential interactions.
Alprazolam (Xanax) is contraindicated to use during pregnancy. Therefore, physicians should be informed if anyone is pregnant or planning to have a child or become pregnant while taking this medication.
Patients should not breastfeed their children if they are taking alprazolam.
Interference With Cognitive & Motor Performance
Until one knows how this medication affects them, activities that require mental alertness and motor coordination, such as driving, should be avoided.
The dosage of this medicine shouldn’t be altered without consulting the treating physician, even if one feels that the medication isn’t working. Benzodiazepines, even when used as recommended, may produce emotional and physical dependence.
This medication shouldn’t be stopped abruptly without consulting the physician since serious withdrawal symptoms can occur.
Key Takeaways: Is It Safe to Take Alprazolam With CBD?
Alprazolam (Xanax) and CBD are both effective in the treatment of anxiety and panic disorders. However, as CBD inhibits the enzymes needed for the metabolism of alprazolam, these can interact easily, leading to adverse effects. Hence, it is generally recommended not to mix these two medications.
However, if anyone is willing to use CBD alongside or replace alprazolam, they must do it under the supervision of a physician. During the concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression.
Cautious dosage titration may be required, especially at the beginning of the treatment. Patients must notify their physician if they experience excessive or prolonged effects that interfere with their normal activities.