Posted on

cbd oil and lupus

Lupus is a chronic condition and, as is true for many autoimmune diseases, it often goes through periods of remission and flare-ups. Dealing with the disease may contribute to psychological disturbances such as anxiety and depression, not to mention the effects of the disease on the nervous system itself. One study showed that depression affects as many as 25% of lupus patients [16] and anxiety affects as many as 37%. Another study [17] confirms that several moods and anxiety disorders are more common in women with SLE compared to the general population.

Cannabidiol (CBD) is one of the major plant compounds [8 found in Cannabis. Though the benefits of CBD are still being studied, its effects have been linked primarily to its interaction with cannabinoid receptors in the body’s endocannabinoid system. The endocannabinoid system is a cell signaling system in the body [9] that helps regulate function and maintain homeostasis. By binding to or interacting with certain receptors (primarily CB1 and CB2 receptors), CBD oil may offer pain-relieving and anti-inflammatory properties, among other benefits.

Taking CBD oil can be unpleasant if you don’t like the natural flavor of hemp oil. With PlusCBD, you can choose from a wide variety of unflavored and flavored options, including recipes sweetened with monk fruit extract. Choose from a wide range of concentrations including both broad-spectrum CBD and whole-plant extracts. They even offer raw CBD oil.

Opioid Addiction

In the study of CBD use [18] mentioned above, the second most common reported reason for taking CBD oil was for anxiety. CBD has been shown to act on the brain’s receptors for serotonin [19] , the neurotransmitter linked to mood. As such, it has shown potential as a treatment for generalized anxiety disorder, panic disorder, PTSD, and other anxiety disorders. Studies using animal models have also shown CBD to exhibit antidepressant effects [20] .

Free Shipping and 15% Off Coupon: “HEALTHCANAL”

You don’t have to pay a fortune to use CBD and you should have the peace of mind knowing your purchase is guaranteed if you’re not fully satisfied. CBD Pure checks off both of these boxes with their affordable pricing and a generous 90-day guarantee. Choose from three concentrations of organic hemp CBD: 300mg, 600mg, or 1,000mg. These oils have a natural hemp flavor and come in either 30ml or 60ml bottles.

15% Off Coupon: “HEALTHCANAL”

Treatment decisions should never be taken lightly, and that applies to “natural” treatments like CBD as well—especially when you take the law into account. Consider the pros and con carefully, and be sure to discuss this option with your doctor. Even if you’re taking it illegally, your doctor needs to know—your health could depend on it. As with any treatment, it’s important to watch for side effects.

It’s too early in the research process for us to be able to say “yes” about many of the claims. However, we’re learning enough to be able to say “it’s possible,” or even, “we think so.”

Richard N. Fogoros, MD, is a retired professor of medicine and board-certified internal medicine physician and cardiologist.

Is CBD Legal?

CBD doesn’t appear to lead to addiction or abuse. It’s also believed to have a low toxicity level, which means it takes a lot to cause an overdose.

Additionally, a 2018 study published in Cellular Immunology found that CBD may alter T-cell activity after spinal cord injury.   Abnormal activity of T-cells (which are part of the immune system) are believed to be involved in lupus.

If you look online, you can find a lot of huge claims about using CBD oil for medicinal purposes. Claims are so glowing, in fact, that you might start to wonder if they can possibly be true. Certainly, when they come from websites that promote marijuana legalization and use, you may be wise to question the veracity.

Then came the 2018 Farm Bill. This piece of legislation was wildly popular in both the Senate, where it was passed in June of 2018, and the House, where it was passed in December of 2018 and then quickly signed into law.   It re-classifies hemp as a legal agricultural product, which makes CBD products legal at the federal level.

His research is one of many new studies at Yale and elsewhere looking at the endocannabinoid system and molecules related to CBD action for use in treating everything from Crohn’s disease to psoriatic arthritis, and he hopes that this new data will be used to help paint a more complete picture about the chemical for future treatment options.

CBD is a form of cannabinoid called “cannabidiol.” Cannabinoids are a type of chemical that binds to CB1 and CB2 receptors found throughout the body. CB1 receptors are mostly located in the nervous system, connective tissues, gonads, glands, and organs; CB2 receptors are primarily found in the immune system, along with the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands, and reproductive organs. (Collectively this is called the endocannabinoid system.)

A lupus diagnosis can be devastating. The disease causes the body’s immune system to attack its own tissues and can affect internal organs—including the brain, heart, and lungs—which can start to deteriorate. Lupus flare-ups can leave patients so fatigued and in pain that they’re unable to do the simplest of things, such as walk, cook, or read. Many can’t go outdoors without layers of sunscreen, because the disease can make them extremely susceptible to sunburn.

What is CBD?

In 2018, Dr. Koumpouras joined a multi-site randomized clinical trial that aims to recruit 100 participants to examine whether a drug using a synthetically created cannabinoid molecule that binds preferentially to CB2 receptors (called Lenabasum) can help ease pain and inflammation in patients with lupus. Participants will receive Lenabasum or a placebo for almost three months and will continue to be monitored for pain and inflammation levels, as well as lupus disease activity. The study is ongoing, but Dr. Koumpouras anticipates that it will wrap up by early next year.

Fotios Koumpouras, MD, is researching a synthetically created cannabinoid molecule that binds preferentially to CB2 receptors (called Lenabasum) to see if it can help ease pain and inflammation in patients with lupus.

This is why he’s exploring a candidate for a new lupus treatment option: a molecule with a cannabinoid template structure that binds to cannabinoid receptors, the same receptors involved in the chemicals found in the marijuana plant.

But whether CBD actually provides those benefits in a significant way remains to be seen. Only a few studies—small ones—have definitively proven the effectiveness of medicines that involve the endocannabinoid system. To date, the only FDA-approved medication containing CBD is Epidiolex, a medication used to treat two rare forms of severe epilepsy—Lennox-Gastaut syndrome and Dravet syndrome, both which begin mostly in infancy and early childhood. In a group of three clinical trials, Epidiolex seemed to reduce the number of seizures significantly. And yet, Vinita Knight, MD, a Yale Medicine pediatric neurologist, says her patients who take Epidiolex have had mixed results. Some have had reductions in seizures and others haven’t shown much improvement. “We’re not seeing as much success as what’s been reported on Facebook and Twitter,” she says, but adds that so far it has only been prescribed for children with the most debilitating and difficult-to-treat seizures. In addition, some researchers believe that CBD works most effectively in combination with other cannabinoids and compounds found in the marijuana plant, in what is known as the “entourage effect.” Thus, it would be less effective as an isolated chemical in pill form, but that, too, remains unproven.