Background: Cannabidiol (CBD)-based treatments for several diseases, including Tourette’s syndrome, multiple sclerosis, epilepsy, movement disorders and glaucoma, are proving to be beneficial and the scientific clinical background of the drug is continuously evolving.
Results: Two patients dropped out due to iatrogenic adverse events and another two patients stopped the treatment early due to lack of any improvement. SF-36 showed significant benefits in the physical component score (P < 0.02), vitality (P < 0.03) and social role functioning (P < 0.02) after the treatment. The administration of hemp oil also significantly reduced body pain according to the SF-36 assessment. No significant differences from the start of treatment to several months post-treatment were detected in role limitations due to emotional reactions (P = 0.02).
Methods: In this anecdotal, retrospective, “compassionate-use”, observational, open-label study, 12 females (age 12-24 years) with severe somatoform and dysautonomic syndrome following HPV vaccination were given sublingual CBD-rich hemp oil drops, 25 mg/kg per day supplemented by 2-5 mg/ml CBD once a week until a maximum dose of 150 mg/ml CBD per day was reached over a 3 month period. Patients’ quality of life was evaluated using the medical outcome short-form health survey questionnaire (SF-36).
Objectives: To investigate the short-term effect of CBD-enriched hemp oil for relieving symptoms and improving the life quality (QOL) in young girls with adverse drug effects (ADRs) following human papillomavirus (HPV) vaccine.
Conclusions: This study demonstrated the safety and tolerability of CBD-rich hemp oil and the primary efficacy endpoint. Randomized controlled trials are warranted to characterize the safety profile and efficacy of this compound.
Genital warts are common and are caused by certain types of HPV. Genital warts can be annoying, but they are treatable and are not dangerous.
You get genital warts from having skin-to-skin contact with someone who’s infected, often during vaginal, anal, and oral sex. Genital warts can be spread even if no one cums, and a penis does not have to go inside a vagina or anus to get them. You can spread them even when you do not have any visible warts or other symptoms, though that is less common. You can also pass genital warts to a baby during vaginal childbirth, but that is pretty rare.
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Genital warts are different from warts you might get elsewhere on your body. So you can not get genital warts by touching yourself (or a partner) with a wart that is on your hand or foot.
Genital warts show up on the skin around your genitals and anus. They are caused by certain types of human papillomavirus (HPV). You might have heard that some types of HPV can cause cancer, but they are not the same kinds that give you genital warts.
HPV can be a tricky STD to understand. It is the most common STD, but most of the time it goes away on its own. Sometimes certain types of “high-risk” HPV can develop into cancer if left untreated. Other “low-risk” types of HPV can cause warts on your vulva, vagina, cervix, rectum, anus, penis, or scrotum. Genital warts are common – about 360,000 people get them each year.
The use of escharotic or caustic treatments for epithelial cancers is based on a centuries-old observation that select plant and mineral extracts could be used to treat topical skin lesions. Two small studies show the efficacy of this treatment in reversing cervical dysplasia in women.21,22This treatment is used for CIN I and II after a satisfactory colposcopy is performed and if there is no disease in the endocervical canal and no glandular cells present. Escharotic treatment for cervical dysplasia involves the local application of a natural enzyme, bromelain, to the surface of the cervix. This is left in place for 15 minutes with heat applied to activate the enzyme. The proteolytic properties in bromelain dissolve the top layer of cells on the cervix which are infected and damaged by the HPV virus. A mixture of zinc chloride and a plant Sanguinaria is applied to the cervix to cause sloughing of abnormal tissue. Zinc chloride is caustic and acts to disrupt the cellular membrane integrity and the mucus over coating to allow the Sangunaria to penetrate the cells. Sanguinaria has been shown to have anti-neoplastic qualities.21 The treatment is performed twice per week with at least two days in between treatments for 4-5 weeks. The ZnCl solution is made by a compounding pharmacist.
Indole-3-carbinol (I3C)is present in all members of the cruciferous vegetable family including cabbage, broccoli, Brussels sprouts, cauliflower, and kale. Studies indicate I3C has the potential to prevent and even treat a number of common cancers, especially those that are estrogen related.In a double-blind, placebo controlled study, 30 patients with biopsy-confirmed CIN II-III were randomized to receive placebo or 200 or 400 mg oral I3C daily for 12 weeks. Three patients did not complete the study. None of the 10 patients in the placebo group had complete regression of CIN. Four of eight patients in the 200-mg/day group and four of nine in the 400-mg/day group had complete regression of CIN.I3C is easily available over the counter as a supplement or simply by eating 4-5 servings of the cruciferous family vegetables a day.
5) Women under 30 should be tested for high risk HPV if the pap comes back as atypical cells of undetermined significance, or ASCUS. This is called reflux testing and can be done from the same sample if liquid based cytology is done.
a) Coriolus versicolor supplementation demonstrated a 72% regression rate in LSIL lesions compared to 47.5% without supplementation.
Cervical cancer ranks 13th on the list of causes of death in women in the U.S. Thanks to the pap smear test precancerous lesions, called dysplasia, are diagnosed more frequently than invasive cervical cancer. Annual screening and early diagnosis give physicians a chance to start treatment and prevent cervical cancer.
6) It is acceptable to discontinue cervical cancer screening between 65 years and 70 years of age in women who have three or more negative cytology test results in a row and no abnormal test results in the past 10 years.
Conventional management for cervical dysplasia includes colposcopy with endocervical sampling to determine the extent and degree of dysplasia which is categorized as cervical intraepithelial neoplasia, CIN, and graded level I, II, or III.The American Society for Coloposcopy and Cervical Pathology, ASCCP, has determined guidelines for conventional management of cervical intraepithelial neoplasia.