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A variety of vape oils, tinctures, salves, and edibles with numbers like 18:1, 4:1, and 1:1 — noting the amount of CBD to THC — have been showing up at dispensaries in recent years in both medical and recreational states. THC will make you high, while its sister compound CBD generally won’t — and has therapeutic potential. Most marijuana strains have around 18 percent THC with less than 1 percent CBD (with THC sometimes being pushed beyond 20 percent).

There is, however, a prescription 1:1 CBD to THC mouth spray called Sativex made in the UK and available in several countries including Spain, Germany, Canada, and Brazil that’s meant to treat spasms in MS patients. It’s undergoing clinical trials in the U.S. Epidiolex, the first FDA-approved cannabis-derived drug in the states, is high in CBD with trace amounts of THC (not enough to have any pharmacological effect). It’s used to treat seizures.

But there’s a method to the madness — one based more on anecdotes than broadly recognized scientific research.

Here’s a rule of thumb: The higher the CBD, the less of a high you’ll get from the THC, both because there’s less of it and CBD generally combats THC’s psychoactive effects, depending on the amount of THC you’ve consumed, according to cannabis researchers and producers.

There’s a flurry of new numbers on marijuana product labels, and the ratios can feel like a confusing math problem.

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Produced in small batches at the company’s Kentucky hemp farm, Spruce doesn’t use high-tech CO2 extraction to make its full-spectrum CBD oil. Instead, Spruce insists that the best combination of CBD, low-THC, and terpenes comes from using a moonshine extraction method. The moonshine gets completely filtered out of the product, leaving no taste or alcohol residue.

With nearly 12,000 reviewers giving it an average of 4.9 stars, there’s little doubt NuLeaf Naturals makes one of the best full-spectrum CBD oils available. Sourced from Colorado hemp farms and available in all 50 states and more than 40 countries, NuLeaf Naturals Full-Spectrum CBD Oil contains 50 milligrams per milliliter of whole-plant hemp extract.

Availability : United States

The Best Full-Spectrum CBD Oil

This curated list features standby products with established reputations and new entrants that are shaking things up in exciting ways. We hope it introduces you to unique, effective, and highly rated CBD products for every kind of wellness regimen or therapeutic need.

Availability : United States

Care By Design offers a lineup of the best 1:1 CBD Oils for fast-acting relief from pain, inflammation, insomnia, and stress. In fact, Care By Design offers CBD-to-THC ratios ranging from 18:1 to 1:1. That flexibility means consumers with different therapeutic needs and preferences can craft their ideal experiences.

Price : $60-$100 — Find it on Weedmaps